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Cellosaurus MGC-803 (CVCL_5334)

[Text version]
Cell line name MGC-803
Synonyms MGC803; MGc80-3
Accession CVCL_5334
Resource Identification Initiative To cite this cell line use: MGC-803 (RRID:CVCL_5334)
Comments Problematic cell line: Possibly contaminated. May be a derivative of HeLa and another cell of unknown origin. The STR profile is highly similar to that of HeLa yet shows some specific differences that suggest a possible hybrid cell line.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00588.
Doubling time: 22.5 hours (PubMed=29683800).
Omics: Secretome proteome analysis by 2D-DE/MS.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Formerly the CCRID database had 2 entries describing this cell line (3111C0001CCC000227, 3131C0001000700084). They were one of the sources for the STR profile of this entry.
Misspelling: BGC-803; Note=Occasionally.
Misspelling: BGC803; Note=Occasionally.
Misspelling: MCG803; GEO=GSM844588.
Disease Gastric mucinous adenocarcinoma (NCIt: C5248)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UI41 (MGC-803/5FU)CVCL_UI42 (MGC-803/DDP)CVCL_VG42 (MGC-803/PTX)
CVCL_UI43 (MGC-803/TA)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=28107433; PubMed=28851942

Markers:
AmelogeninX
CSF1PO9,10,12
D2S44110,11
D2S133817,24
D3S135815,18
D5S81810,11,12
D6S104318,19
D7S82011,12
D8S117912,14
D12S39117,20,26
D13S3177,13.3
D16S5399,11
D18S5113
D19S43313
D21S1127,28
FGA18,21
Penta D8,15
Penta E7,10,16,17
TH017,9
TPOX12
vWA16,17,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

DOI=10.1007/BF02948354
Xiao H., Dong Z.-W., Shou C.-C.
Induction of apoptosis in human gastric carcinoma cell line MGC-803 by monoclonal antibody PD4.
Chin. J. Cancer Res. 10:169-173(1998)

PubMed=24743803
Huang H., Han Y., Wu J., Tian Z.-H., Qu L.-K., Shou C.-C.
Establishment of drug resistant cell line of MGC-803 and analysis of differential secretome.
Beijing Da Xue Xue Bao Yi Xue Ban 46:183-189(2014)

PubMed=28107433; DOI=10.1371/journal.pone.0170384
Huang Y.-Q., Liu Y.-H., Zheng C.-Y., Shen C.
Investigation of cross-contamination and misidentification of 278 widely used tumor cell lines.
PLoS ONE 12:E0170384-E0170384(2017)

PubMed=28851942; DOI=10.1038/s41598-017-09660-w
Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q.
A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines.
Sci. Rep. 7:9774-9774(2017)

PubMed=29683800; DOI=10.1097/CAD.0000000000000601
Fu L., Yin F., Li X.-R., Han B.-K., Zhang C., Wang J.-W., Wang Y.-Q., Bi Y.-F., Liu H.-M.
Generation and characterization of a paclitaxel-resistant human gastric carcinoma cell line.
Anticancer Drugs 29:491-502(2018)

PubMed=29717028; DOI=10.1042/BSR20180277
Zhang Y.-Q., Yu S., Zhang Z.-Z., Zhao G., Xu J.
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018)

Cross-references
Anatomy/cell type resources BTO; BTO:0004953
Chemistry resources ChEMBL-Cells; CHEMBL3706567
ChEMBL-Targets; CHEMBL3706566
PubChem_Cell_line; CVCL_5334
Encyclopedic resources Wikidata; Q54905425
Experimental variables resources EFO; EFO_0006286
Gene expression databases GEO; GSM844588
GEO; GSM1374671
Polymorphism and mutation databases Cosmic; 2267321
IARC_TP53; 24858
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number26