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Cellosaurus KMT-2 (CVCL_5301)

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Cell line name KMT-2
Accession CVCL_5301
Resource Identification Initiative To cite this cell line use: KMT-2 (RRID:CVCL_5301)
Comments Problematic cell line: Contaminated. Shown to be a KG-1 derivative (PubMed=16643607; PubMed=20143388). Originally thought to originate from umbilical cord blood cells.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00229.
Population: Caucasian.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:3688; FGFR1 + HGNC; HGNC:23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Acute myeloid leukemia without maturation (NCIt: C3249)
Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0374 (KG-1)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=KMT-2
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2198959; DOI=10.1182/blood.V76.3.501.501
Sumie Tamura, Minoru Sugawara, Hiroshi Tanaka, Emiko Tezuka, Shin-ichi Nihira, Chikara Miyamoto, Toshio Suda, Yumiko Ohta;
A new hematopoietic cell line, KMT-2, having human interleukin-3 receptors.
Blood 76:501-507(1990)

PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4
Kaoru Tohyama;
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x
Kaori Yoshino, Emi Iimura, Kaoru Saijo, Satsuki Iwase, Kiyoko Fukami, Tadao Ohno, Yuichi Obata, Yukio Nakamura;
Essential role for gene profiling analysis in the authentication of human cell lines.
Hum. Cell 19:43-48(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) RCB; RCB0712 - Discontinued
Cell line databases/resources cancercelllines; CVCL_5301
Biological sample resources BioSample; SAMN03151819
Encyclopedic resources Wikidata; Q54900194
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27