ID   KMT-2
AC   CVCL_5301
DR   BioSample; SAMN03151819
DR   cancercelllines; CVCL_5301
DR   RCB; RCB0712
DR   Wikidata; Q54900194
RX   PubMed=2198959;
RX   PubMed=9195772;
RX   PubMed=16643607;
RX   PubMed=20143388;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=KMT-2
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a KG-1 derivative (PubMed=16643607; PubMed=20143388). Originally thought to originate from umbilical cord blood cells.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00229.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:3688; FGFR1 + HGNC; HGNC:23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Discontinued: RCB; RCB0712; true.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0374 ! KG-1
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=2198959; DOI=10.1182/blood.V76.3.501.501;
RA   Tamura S., Sugawara M., Tanaka H., Tezuka E., Nihira S.-i.,
RA   Miyamoto C., Suda T., Ohta Y.;
RT   "A new hematopoietic cell line, KMT-2, having human interleukin-3
RT   receptors.";
RL   Blood 76:501-507(1990).
//
RX   PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4;
RA   Tohyama K.;
RT   "Human factor-dependent leukemia cell lines.";
RL   Int. J. Hematol. 65:309-317(1997).
//
RX   PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x;
RA   Yoshino K., Iimura E., Saijo K., Iwase S., Fukami K., Ohno T.,
RA   Obata Y., Nakamura Y.;
RT   "Essential role for gene profiling analysis in the authentication of
RT   human cell lines.";
RL   Hum. Cell 19:43-48(2006).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//