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Cellosaurus OCI-AML3/HaABCG2 clone 6.2 (CVCL_5227)

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Cell line name OCI-AML3/HaABCG2 clone 6.2
Synonyms OCI-AML6.2; OCI AML6.2; AML6.2
Accession CVCL_5227
Resource Identification Initiative To cite this cell line use: OCI-AML3/HaABCG2 clone 6.2 (RRID:CVCL_5227)
Comments Population: Caucasian.
Characteristics: High level of expression of ABCG2 (PubMed=12393637).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:74; ABCG2.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:2978; DNMT3A; Simple; p.Arg882Cys (c.2644C>T); ClinVar=VCV000375882; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7910; NPM1; Simple; p.Trp288Cysfs*12 (c.860_863dupTCTG); ClinVar=VCV000013998; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Homozygous (from parent cell line).
Disease Adult acute myelomonocytic leukemia (NCIt: C7962)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1844 (OCI-AML-3)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=12393637; DOI=10.1182/blood-2002-01-0271
Brian L. Abbott, Anne-Marie Colapietro, Yu-Xiao Elizabeth Barnes, Frank C. Marini, Michael Andreeff, Brian P. Sorrentino;
Low levels of ABCG2 expression in adult AML blast samples.
Blood 100:4594-4601(2002)

PubMed=21679421; DOI=10.1186/1471-2407-11-254; PMCID=PMC3146447
Martin Grundy, Claire Seedhouse, Nigel H. Russell, Monica Pallis;
P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the aurora-B kinase inhibitor barasertib-hQPA.
BMC Cancer 11:254.1-254.13(2011)

Cross-references
Encyclopedic resources Wikidata; Q54931746
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number17