Cellosaurus cell line LAD 1 (CVCL

Cellosaurus LAD 1 (CVCL_5220)

Cross-references
Cell line name	LAD 1
Synonyms	LAD1; LADR; Laboratory of Allergic Diseases 1
Accession	CVCL_5220
Resource Identification Initiative	To cite this cell line use: LAD 1 (RRID:CVCL_5220)
Comments	Characteristics: KITLG dependent. Doubling time: ~28 days (DOI=10.1016/j.jaci.2018.12.550). Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. Cell type: Mast cell; CL=CL_0000097.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_0387 ! LAD 2
Sex of cell	Male
Age at sampling	44Y
Category	Factor-dependent cell line
Web pages	Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=LAD1
Publications	PubMed=12801524; DOI=10.1016/S0145-2126(02)00343-0 Arnold S. Kirshenbaum, Cem Akin, Ya-Lin Wu, Menachem Rottem, Julie P. Goff, Michael A. Beaven, V. Koneti Rao, Dean D. Metcalfe; Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk. Res. 27:677-682(2003) PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8 Egle Passante; Mast cell and basophil cell lines: a compendium. Methods Mol. Biol. 1192:101-113(2014) DOI=10.1016/j.jaci.2018.12.550 Arnold S. Kirshenbaum, Yu-Zhi Yin, J. Bruce Sundstrom, Geethani Bandara, Dean D. Metcalfe; Characterization and comparison of human LAD1 mast cells with human LAD2 mast cells. J. Allergy Clin. Immunol. 143 Suppl. 1:AB180.547-AB180.547(2019) PubMed=31698677; DOI=10.3390/ijms20225520; PMCID=PMC6888318 Arnold S. Kirshenbaum, Yu-Zhi Yin, J. Bruce Sundstrom, Geethani Bandara, Dean D. Metcalfe; Description and characterization of a novel human mast cell line for scientific study. Int. J. Mol. Sci. 20:5520.1-5520.9(2019)
Cell line collections (Providers)	ABM; T8156
Encyclopedic resources	Wikidata; Q54901896
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	16