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Cellosaurus LAD 2 (CVCL_0387)

[Text version]
Cell line name LAD 2
Synonyms LAD2; LAD-2; Laboratory of Allergic Diseases 2
Accession CVCL_0387
Resource Identification Initiative To cite this cell line use: LAD 2 (RRID:CVCL_0387)
Comments Characteristics: KITLG dependent.
Doubling time: ~14 days (DOI=10.1016/j.jaci.2018.12.550).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mast cell; CL=CL_0000097.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5220 ! LAD 1
Sex of cell Male
Age at sampling 44Y
Category Factor-dependent cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=LAD2
Publications

PubMed=12801524; DOI=10.1016/S0145-2126(02)00343-0
Kirshenbaum A.S., Akin C., Wu Y.-L., Rottem M., Goff J.P., Beaven M.A., Rao V.K., Metcalfe D.D.
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.
Leuk. Res. 27:677-682(2003)

PubMed=20814942; DOI=10.1002/0471142735.im0737s90; PMCID=PMC2923748
Radinger M., Jensen B.M., Kuehn H.S., Kirshenbaum A.S., Gilfillan A.M.
Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood.
Curr. Protoc. Immunol. 90:7.37.1-7.37.12(2010)

DOI=10.1016/j.jaci.2013.12.226
Kirshenbaum A.S., Petrik A., Walsh R., Vepa S., Metcalfe D.D.
Worldwide impact Of LAD2 mast cell line on mast cell biology research.
J. Allergy Clin. Immunol. 133 Suppl. 1:AB57-AB57(2014)

PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8
Passante E.
Mast cell and basophil cell lines: a compendium.
Methods Mol. Biol. 1192:101-113(2014)

PubMed=25195635; DOI=10.1159/000365729; PMCID=PMC4201868
Kirshenbaum A.S., Petrik A., Walsh R., Kirby T.L., Vepa S., Wangsa D., Ried T., Metcalfe D.D.
A ten-year retrospective analysis of the distribution, use and phenotypic characteristics of the LAD2 human mast cell line.
Int. Arch. Allergy Immunol. 164:265-270(2014)

DOI=10.1016/j.jaci.2018.12.550
Kirshenbaum A.S., Yin Y., Sundstrom J.B., Bandara G., Metcalfe D.D.
Characterization and comparison of human LAD1 mast cells with human LAD2 mast cells.
J. Allergy Clin. Immunol. 143 Suppl. 1:AB180-AB180(2019)

PubMed=31698677; DOI=10.3390/ijms20225520; PMCID=PMC6888318
Kirshenbaum A.S., Yin Y.-Z., Sundstrom J.B., Bandara G., Metcalfe D.D.
Description and characterization of a novel human mast cell line for scientific study.
Int. J. Mol. Sci. 20:5520.1-5520.9(2019)

Cross-references
Cell line databases/resources MCCL; MCC:0000282
Anatomy/cell type resources BTO; BTO_0004139
Chemistry resources ChEMBL-Cells; CHEMBL4483145
ChEMBL-Targets; CHEMBL4483253
PubChem_Cell_line; CVCL_0387
Encyclopedic resources Wikidata; Q54901897
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number18