Cellosaurus logo
expasy logo

Cellosaurus LAD 2 (CVCL_0387)

[Text][XML][JSON]
Cell line name LAD 2
Synonyms LAD2; LAD-2; Laboratory of Allergic Diseases 2
Accession CVCL_0387
Resource Identification Initiative To cite this cell line use: LAD 2 (RRID:CVCL_0387)
Comments Characteristics: KITLG dependent.
Doubling time: ~14 days (DOI=10.1016/j.jaci.2018.12.550).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mast cell; CL=CL_0000097.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5220 ! LAD 1
Sex of cell Male
Age at sampling 44Y
Category Factor-dependent cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=LAD2
Publications

PubMed=12801524; DOI=10.1016/S0145-2126(02)00343-0
Arnold S. Kirshenbaum, Cem Akin, Ya-Lin Wu, Menachem Rottem, Julie P. Goff, Michael A. Beaven, V. Koneti Rao, Dean D. Metcalfe;
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.
Leuk. Res. 27:677-682(2003)

PubMed=20814942; DOI=10.1002/0471142735.im0737s90; PMCID=PMC2923748
Madeleine Radinger, Bettina Margrethe Jensen, Hye Sun Kuehn, Arnold S. Kirshenbaum, Alasdair M. Gilfillan;
Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood.
Curr. Protoc. Immunol. 90:7.37.1-7.37.12(2010)

DOI=10.1016/j.jaci.2013.12.226
Arnold S. Kirshenbaum, Amy Petrik, Rosemary Walsh, Sury Vepa, Dean D. Metcalfe;
Worldwide impact Of LAD2 mast cell line on mast cell biology research.
J. Allergy Clin. Immunol. 133 Suppl. 1:AB57-AB57(2014)

PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8
Egle Passante;
Mast cell and basophil cell lines: a compendium.
Methods Mol. Biol. 1192:101-113(2014)

PubMed=25195635; DOI=10.1159/000365729; PMCID=PMC4201868
Arnold S. Kirshenbaum, Amy Petrik, Rosemary Walsh, Tara L. Kirby, Sury Vepa, Danny Wangsa, Thomas Ried, Dean D. Metcalfe;
A ten-year retrospective analysis of the distribution, use and phenotypic characteristics of the LAD2 human mast cell line.
Int. Arch. Allergy Immunol. 164:265-270(2014)

DOI=10.1016/j.jaci.2018.12.550
Arnold S. Kirshenbaum, Yu-Zhi Yin, J. Bruce Sundstrom, Geethani Bandara, Dean D. Metcalfe;
Characterization and comparison of human LAD1 mast cells with human LAD2 mast cells.
J. Allergy Clin. Immunol. 143 Suppl. 1:AB180.547-AB180.547(2019)

PubMed=31698677; DOI=10.3390/ijms20225520; PMCID=PMC6888318
Arnold S. Kirshenbaum, Yu-Zhi Yin, J. Bruce Sundstrom, Geethani Bandara, Dean D. Metcalfe;
Description and characterization of a novel human mast cell line for scientific study.
Int. J. Mol. Sci. 20:5520.1-5520.9(2019)

Cross-references
Cell line collections (Providers) ABM; T8157
Cell line databases/resources MCCL; MCC:0000282
Anatomy/cell type resources BTO; BTO_0004139
Chemistry resources ChEMBL-Cells; CHEMBL4483145
ChEMBL-Targets; CHEMBL4483253
PubChem_Cell_line; CVCL_0387
Encyclopedic resources Wikidata; Q54901897
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number19