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Cellosaurus Y-MESO-14 (CVCL_5179)

[Text version]
Cell line name Y-MESO-14
Synonyms Y-Meso-14
Accession CVCL_5179
Resource Identification Initiative To cite this cell line use: Y-MESO-14 (RRID:CVCL_5179)
Comments Population: Japanese.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Sequence variations
  • Gene deletion; HGNC; HGNC:6515; LATS2; Zygosity=Homozygous (PubMed=21245096).
  • Mutation; HGNC; HGNC:950; BAP1; Simple; p.Lys116Glyfs*5 (c.349_359del11); Zygosity=Unspecified (PubMed=26011428).
  • Mutation; HGNC; HGNC:7773; NF2; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000457921; Zygosity=Unspecified (PubMed=21245096).
Disease Pleural biphasic mesothelioma (NCIt: C45665)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D2U3 (Y-MESO-14/hPDPN)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=19380521; DOI=10.1093/carcin/bgp097
Koji Kawaguchi, Hideki Murakami, Tetsuo Taniguchi, Makiko Fujii, Shigehisa Kawata, Takayuki Fukui, Yutaka Kondo, Hirotaka Osada, Noriyasu Usami, Kohei Yokoi, Yuichi Ueda ...Show all 16 authors... , Yasushi Yatabe, Masafumi Ito, Yoshitsugu Horio, Toyoaki Hida, Yoshitaka Sekido; Show fewer authors
Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
Carcinogenesis 30:1097-1105(2009)

PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164
Hideki Murakami, Tetsuya Mizuno, Tetsuo Taniguchi, Makiko Fujii, Futoshi Ishiguro, Takayuki Fukui, Shinya Akatsuka, Yoshitsugu Horio, Toyoaki Hida, Yutaka Kondo, Shinya Toyokuni ...Show all 13 authors... , Hirotaka Osada, Yoshitaka Sekido; Show fewer authors
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Cancer Res. 71:873-883(2011)

PubMed=22286761; DOI=10.1038/onc.2012.5
Tetsuya Mizuno, Hideki Murakami, Makiko Fujii, Futoshi Ishiguro, Issei Tanaka, Yutaka Kondo, Shinya Akatsuka, Shinya Toyokuni, Kohei Yokoi, Hirotaka Osada, Yoshitaka Sekido;
YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.
Oncogene 31:5117-5122(2012)

PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387
Shuhei Hakiri, Hirotaka Osada, Futoshi Ishiguro, Hideki Murakami, Yuko Murakami-Tonami, Kohei Yokoi, Yoshitaka Sekido;
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
T. Kato, Tatsuhiro Sato, Kohei Yokoi, Yoshitaka Sekido;
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

Cross-references
Cell line collections (Providers) RCB; RCB5668
Cell line databases/resources cancercelllines; CVCL_5179
Encyclopedic resources Wikidata; Q54995139
Gene expression databases GEO; GSM552527
GEO; GSM850302
Polymorphism and mutation databases Cosmic; 2759219
Progenetix; CVCL_5179
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number18