Cellosaurus cell line SNU-254 (CVCL

Cellosaurus SNU-254 (CVCL_5041)

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Cell line name

SNU-254

Synonyms

SNU254

Accession

CVCL_5041

Resource Identification Initiative

To cite this cell line use: SNU-254 (RRID:CVCL_5041)

Comments

Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 50 hours (PubMed=20176655).
Microsatellite instability: Stable (MSS) (PubMed=20176655; PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.

Sequence variations

Mutation; HGNC; HGNC:583; APC; Simple; p.Leu1488Tyrfs*19 (c.4463delT); ClinVar=VCV000428136; Zygosity=Unspecified (PubMed=20176655).
Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20176655).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Unspecified (PubMed=20176655).

Disease

Rectal adenocarcinoma (NCIt: C9383)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

61Y

Category

Cancer cell line

STR profile

Source(s): KCLB=00254; PubMed=20176655; PubMed=25926053

Markers:

Amelogenin	X
CSF1PO	10,11
D2S1338	23
D3S1358	16,17
D5S818	10,11
D7S820	11,13 (KCLB=00254; PubMed=20176655) 13 (PubMed=25926053)
D8S1179	13,15
D13S317	11
D16S539	9
D18S51	12
D19S433	12,15.2
D21S11	31
FGA	24,25
TH01	7
TPOX	8,12
vWA	14,17

Publications

PubMed=20176655; DOI=10.1093/carcin/bgq043
Ja-Lok Ku, Young-Kyoung Shin, Duck-Woo Kim, Kyung-Hee Kim, Jin-Sung Choi, Sung-Hye Hong, You-Kyung Jeon, Sung-Hee Kim, Hong-Sun Kim, Jae-Hyun Park, Il-Jin Kim, Jae-Gahb Park;
Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers.
Carcinogenesis 31:1003-1009(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references

Cell line collections (Providers)

KCLB; 00254

Cell line databases/resources

cancercelllines; CVCL_5041
ColonAtlas; SNU254

Encyclopedic resources

Wikidata; Q54955157

Gene expression databases

GEO; GSM1448207

Polymorphism and mutation databases

Cosmic; 1322283
IARC_TP53; 28469

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number