ID   SNU-254
AC   CVCL_5041
SY   SNU254
DR   cancercelllines; CVCL_5041
DR   ColonAtlas; SNU254
DR   Cosmic; 1322283
DR   GEO; GSM1448207
DR   IARC_TP53; 28469
DR   KCLB; 00254
DR   Wikidata; Q54955157
RX   PubMed=20176655;
RX   PubMed=25926053;
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Population: Korean.
CC   Doubling time: 50 hours (PubMed=20176655).
CC   Microsatellite instability: Stable (MSS) (PubMed=20176655; PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Leu1488Tyrfs*19 (c.4463delT); ClinVar=VCV000428136; Zygosity=Unspecified (PubMed=20176655).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20176655).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Unspecified (PubMed=20176655).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
ST   Source(s): KCLB=00254; PubMed=20176655; PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 9
ST   D18S51: 12
ST   D19S433: 12,15.2
ST   D21S11: 31
ST   D2S1338: 23
ST   D3S1358: 16,17
ST   D5S818: 10,11
ST   D7S820: 11,13 (KCLB=00254; PubMed=20176655)
ST   D7S820: 13 (PubMed=25926053)
ST   D8S1179: 13,15
ST   FGA: 24,25
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 14,17
DI   NCIt; C9383; Rectal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=20176655; DOI=10.1093/carcin/bgq043;
RA   Ku J.-L., Shin Y.-K., Kim D.-W., Kim K.-H., Choi J.-S., Hong S.-H.,
RA   Jeon Y.-K., Kim S.-H., Kim H.-S., Park J.-H., Kim I.-J., Park J.-G.;
RT   "Establishment and characterization of 13 human colorectal carcinoma
RT   cell lines: mutations of genes and expressions of drug-sensitivity
RT   genes and cancer stem cell markers.";
RL   Carcinogenesis 31:1003-1009(2010).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//