Cellosaurus cell line UKF-Rhb-1rVCR10 (CVCL

Cellosaurus UKF-Rhb-1rVCR10 (CVCL_4Z18)

Cross-references
Cell line name	UKF-Rhb-1rVCR10
Accession	CVCL_4Z18
Resource Identification Initiative	To cite this cell line use: UKF-Rhb-1rVCR10 (RRID:CVCL_4Z18)
Comments	Part of: Resistant Cancer Cell Line (RCCL) collection. Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR). Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys291Ter (c.871A>T); Zygosity=Unspecified (PubMed=19147553).
Disease	Alveolar rhabdomyosarcoma (NCIt: C3749) Alveolar rhabdomyosarcoma (ORDO: Orphanet_99756)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4Z17 (UKF-Rhb-1)
Category	Cancer cell line
Web pages	Provider; RCCL; -; https://www.wass-michaelislab.org/rccl.php
Publications	PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856 Martin Michaelis, Florian Rothweiler, Denise Klassert, Andreas von Deimling, Kristoffer Weber, Boris Fehse, Bernd Kammerer, Hans-Wilhelm Doerr, Jindrich Cinatl Jr.; Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3. Cancer Res. 69:416-421(2009) PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738 Martin Michaelis, Florian Rothweiler, Susanne Barth, Jaroslaw Cinatl, Marijke van Rikxoort, Nadine Loschmann, Yvonne Voges, Rainer Breitling, Andreas von Deimling, Franz Rodel, Kristoffer Weber ...Show all 17 authors... , Boris Fehse, Elisabeth Mack, Thorsten Stiewe, Hans-Wilhelm Doerr, Daniel Speidel, Jindrich Cinatl Jr.; Show fewer authors Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death Dis. 2:e243.1-e243.8(2011)
Encyclopedic resources	Wikidata; Q54990419
Entry history
Entry creation	14-Dec-2015
Last entry update	10-Apr-2025
Version number	11