Cellosaurus L5178Y TK+/- (clone 3.7.2C) (IVGT) (CVCL_4W65)
| Cell line name | L5178Y TK+/- (clone 3.7.2C) (IVGT) |
|---|---|
| Synonyms | L5178Y tk+/- 3.7.2c (IVGT); L5178Y TK +/-3.7.2c (IVGT) |
| Accession | CVCL_4W65 |
| Resource Identification Initiative | To cite this cell line use: L5178Y TK+/- (clone 3.7.2C) (IVGT) (RRID:CVCL_4W65) |
| Comments | Part of: In Vitro Genetic Toxicity (IVGT) cell line panel. Biotechnology: Used for mutation assays to predict the carcinogenic potential of chemicals. Allows the quantitation of forward mutations at the thymidine kinase (TK) locus. These TK heterozygous cells are treated with a range of doses of the test substance. The cells are incubated, washed free of tests substance and allowed time for the phenotypic expression of newly induced mutations (from parent cell line). Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA). Derived from site: In situ; Thymus; UBERON=UBERON_0002370. Cell type: T-cell; CL=CL_0000084. |
| Disease | Mouse thymic lymphoma (NCIt: C134997) |
| Species of origin | Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2. |
| Hierarchy | Parent: CVCL_6665 (L5178Y TK+/- (clone 3.7.2C)) |
| Sex of cell | Female |
| Age at sampling | 8M |
| Category | Cancer cell line |
| Publications | PubMed=27692294; DOI=10.1016/j.mrgentox.2016.08.001 |
| Cross-references | |
| Cell line collections (Providers) | ECACC; 12080201
JCRB; JCRB0709.2 |
| Encyclopedic resources | Wikidata; Q54901040 |
| Entry history | |
| Entry creation | 14-Dec-2015 |
| Last entry update | 14-Aug-2025 |
| Version number | 11 |