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Cellosaurus Huh7S1 (CVCL_4W53)

[Text version]
Cell line name Huh7S1
Accession CVCL_4W53
Resource Identification Initiative To cite this cell line use: Huh7S1 (RRID:CVCL_4W53)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:50924; Sorafenib (Nexavar).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=23111106; DOI=10.1016/j.canlet.2012.10.021
van Malenstein H., Dekervel J., Verslype C., Van Cutsem E., Windmolders P., Nevens F., van Pelt J.F.
Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth.
Cancer Lett. 329:74-83(2013)

Cell line databases/resources cancercelllines; CVCL_4W53
Encyclopedic resources Wikidata; Q54896862
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number13