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Cellosaurus HepG2S3 (CVCL_4W44)

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Cell line name HepG2S3
Accession CVCL_4W44
Resource Identification Initiative To cite this cell line use: HepG2S3 (RRID:CVCL_4W44)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50924; Sorafenib (Nexavar).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=23111106; DOI=10.1016/j.canlet.2012.10.021
Hannah van Malenstein, Jeroen Dekervel, Chris Verslype, Eric Van Cutsem, Petra Windmolders, Frederik Nevens, Jos F. van Pelt;
Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth.
Cancer Lett. 329:74-83(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4W44
Encyclopedic resources Wikidata; Q54882863
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number14