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Cellosaurus SKW3/Clo (CVCL_4V58)

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Cell line name SKW3/Clo
Accession CVCL_4V58
Resource Identification Initiative To cite this cell line use: SKW3/Clo (RRID:CVCL_4V58)
Comments Problematic cell line: Contaminated. Parent cell line (SKW-3) has been shown to be a KE-37 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_681569; Clofarabine (CAFdA).
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2197 (SKW-3)
Sex of cell Male
Age at sampling 27Y
Category Cancer cell line
Publications

PubMed=25461250; DOI=10.1016/j.exphem.2014.11.001
Miho Yamanishi, Hidehiko Narazaki, Takeshi Asano;
Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase.
Exp. Hematol. 43:207-214(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V58
Encyclopedic resources Wikidata; Q54954817
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number13