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Cellosaurus A431/TPT (CVCL_4V41)

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Cell line name A431/TPT
Accession CVCL_4V41
Resource Identification Initiative To cite this cell line use: A431/TPT (RRID:CVCL_4V41)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63632; Topotecan.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; HGNC:3236; EGFR + HGNC; HGNC:9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=19765546; DOI=10.1016/j.bcp.2009.09.012
Valentina Zuco, Rosanna Supino, Enrica Favini, Monica Tortoreto, Raffaella Cincinelli, Anna Cleta Croce, Federica Bucci, Claudio Pisano, Franco Zunino;
Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma.
Biochem. Pharmacol. 79:535-541(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V41
Encyclopedic resources Wikidata; Q54606919
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number13