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Cellosaurus U-CH2 (CVCL_4989)

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Cell line name U-CH2
Synonyms UCH-2; UCH2
Accession CVCL_4989
Resource Identification Initiative To cite this cell line use: U-CH2 (RRID:CVCL_4989)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 4 days (PubMed=26183925); ~5-7 days (DSMZ=ACC-749); 3 days (Chordoma Foundation).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
HLA typing Source: Chordoma Foundation
Class I
HLA-AA*11:01
HLA-BB*07
HLA-CC*07:02
Class II
HLA-DQDQA1*02:01
DQB1*03
HLA-DRDRB4*01:03N
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.92
East Asian, North0
East Asian, South0.34
South Asian1.36
European, North67.93
European, South29.44
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3218; Cosmic-CLP=1503373; DSMZ=ACC-749; PubMed=21253487; PubMed=26183925; PubMed=27102572; PubMed=28835717

Markers:
AmelogeninX
CSF1PO11,12
D1S165614.3,15
D2S44110,11.3
D2S133824
D3S135817
D5S81810,11
D7S8208,12
D8S117913
D10S124813,16
D12S39118,19
D13S31711
D16S53912
D18S5112,17.3 (DSMZ=ACC-749)
12,18 (PubMed=26183925; PubMed=27102572; PubMed=28835717)
D19S43315.2,17 (PubMed=26183925; PubMed=27102572)
16,17 (DSMZ=ACC-749)
D21S1129,30
D22S104515
FGA21,22.2
Penta D12,13
Penta E12,15
TH016 (Cosmic-CLP=1503373)
6,9.3 (PubMed=21253487)
9.3 (ATCC=CRL-3218; DSMZ=ACC-749; PubMed=26183925; PubMed=27102572)
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch2/
Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/UCH1_Crawford_protocol.pdf
Publications

PubMed=21253487; DOI=10.1155/2010/630129; PMCID=PMC3022207
Silke Bruderlein, Joshua B. Sommer, Paul S. Meltzer, Su-Feng Li, Takuya Osada, David Ng, Peter Moller, David A. Alcorta, Michael J. Kelley;
Molecular characterization of putative chordoma cell lines.
Sarcoma 2010:630129.1-630129.14(2010)

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
Adrian von Witzleben, Lukas T. Goerttler, Ralf Marienfeld, Holger Barth, Andre Lechel, Kevin Mellert, Michael Bohm, Marko Kornmann, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 15 authors... , Adrienne M. Flanagan, Peter Moller, Silke Bruderlein, Thomas F.E. Barth; Show fewer authors
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Susanne Scheipl, Michelle Barnard, Lucia Cottone, Mette Jorgensen, David Harold Drewry, William J. Zuercher, Fabrice Turlais, Hong-Tao Ye, Ana P. Leite, James A. Smith, Andreas Leithner ...Show all 19 authors... , Peter Moller, Silke Bruderlein, Naomi Guppy, Fernanda Amary, Roberto Tirabosco, Sandra J. Strauss, Nischalan Pillay, Adrienne M. Flanagan; Show fewer authors
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

PubMed=28835717; DOI=10.1038/s41598-017-10044-3; PMCID=PMC5569021
Roberta Bosotti, Paola Magnaghi, Sebastiano Di Bella, Liviana Cozzi, Carlo Cusi, Fabio Bozzi, Nicola Beltrami, Giovanni Carapezza, Dario Ballinari, Nadia Amboldi, Rosita Lupi ...Show all 18 authors... , Alessio Somaschini, Laura Raddrizzani, Barbara Salom, Arturo Galvani, Silvia Stacchiotti, Elena Tamborini, Antonella Isacchi; Show fewer authors
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1.
Sci. Rep. 7:9226-9226(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-3218
DSMZ; ACC-749
Cell line databases/resources Cell_Model_Passport; SIDM01185
Cosmic-CLP; 1503373
DepMap; ACH-002204
DSMZCellDive; ACC-749
Chemistry resources PharmacoDB; UCH2_1627_2019
Encyclopedic resources Wikidata; Q54973617
Gene expression databases GEO; GSM1670565
GEO; GSM1673847
GEO; GSM1673848
Polymorphism and mutation databases Cosmic; 2663858
Proteomic databases PRIDE; PXD030304
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30