ID   U-CH2
AC   CVCL_4989
SY   UCH-2; UCH2
DR   ATCC; CRL-3218
DR   Cell_Model_Passport; SIDM01185
DR   Cosmic; 2663858
DR   Cosmic-CLP; 1503373
DR   DepMap; ACH-002204
DR   DSMZ; ACC-749
DR   DSMZCellDive; ACC-749
DR   GEO; GSM1670565
DR   GEO; GSM1673847
DR   GEO; GSM1673848
DR   PharmacoDB; UCH2_1627_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54973617
RX   PubMed=21253487;
RX   PubMed=26183925;
RX   PubMed=27102572;
RX   PubMed=27397505;
RX   PubMed=28515451;
RX   PubMed=28835717;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch2/
WW   Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/UCH1_Crawford_protocol.pdf
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: ~1 week (Note=At 11th passage) (PubMed=21253487); 4 days (PubMed=26183925); ~5-7 days (DSMZ=ACC-749); 3 days (Chordoma Foundation).
CC   HLA typing: A*11:01; B*07; C*07:02; DQA1*02:01; DQB1*03; DRB4*01:03N (Chordoma Foundation).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Genome ancestry: African=0%; Native American=0.92%; East Asian, North=0%; East Asian, South=0.34%; South Asian=1.36%; European, North=67.93%; European, South=29.44% (PubMed=30894373).
ST   Source(s): ATCC=CRL-3218; Cosmic-CLP=1503373; DSMZ=ACC-749; PubMed=21253487; PubMed=26183925; PubMed=27102572; PubMed=28835717
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D10S1248: 13,16
ST   D12S391: 18,19
ST   D13S317: 11
ST   D16S539: 12
ST   D18S51: 12,17.3 (DSMZ=ACC-749)
ST   D18S51: 12,18 (PubMed=26183925; PubMed=27102572; PubMed=28835717)
ST   D19S433: 15.2,17 (PubMed=26183925; PubMed=27102572)
ST   D19S433: 16,17 (DSMZ=ACC-749)
ST   D1S1656: 14.3,15
ST   D21S11: 29,30
ST   D22S1045: 15
ST   D2S1338: 24
ST   D2S441: 10,11.3
ST   D3S1358: 17
ST   D5S818: 10,11
ST   D7S820: 8,12
ST   D8S1179: 13
ST   FGA: 21,22.2
ST   Penta D: 12,13
ST   Penta E: 12,15
ST   TH01: 6 (Cosmic-CLP=1503373)
ST   TH01: 6,9.3 (PubMed=21253487)
ST   TH01: 9.3 (ATCC=CRL-3218; DSMZ=ACC-749; PubMed=26183925; PubMed=27102572)
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C129927; Sacral chordoma
DI   ORDO; Orphanet_178; Chordoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   72Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 31
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270;
RA   von Witzleben, Adrian
RA   Goerttler, Lukas T.
RA   Marienfeld, Ralf
RA   Barth, Holger
RA   Lechel, Andre
RA   Mellert, Kevin
RA   Bohm, Michael J.
RA   Kornmann, Marko
RA   Mayer-Steinacker, Regine
RA   von Baer, Alexandra
RA   Schultheiss, Markus
RA   Flanagan, Adrienne Margaret
RA   Moller, Peter
RA   Bruderlein, Silke
RA   Barth, Thomas F.E.
RT   "Preclinical characterization of novel chordoma cell systems and their
RT   targeting by pharmocological inhibitors of the CDK4/6 cell-cycle
RT   pathway.";
RL   Cancer Res. 75:3823-3831(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709;
RA   Jager, Daniela
RA   Barth, Thomas F.E.
RA   Bruderlein, Silke
RA   Scheuerle, Angelika
RA   Rinner, Beate
RA   von Witzleben, Adrian
RA   Lechel, Andre
RA   Meyer, Patrick
RA   Mayer-Steinacker, Regine
RA   von Baer, Alexandra
RA   Schultheiss, Markus
RA   Wirtz, Christian R.
RA   Moller, Peter
RA   Mellert, Kevin
RT   "HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and
RT   sacral chordomas.";
RL   Sci. Rep. 7:2032.1-2032.12(2017).
//
RX   PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416;
RA   Scheipl, Susanne
RA   Barnard, Michelle
RA   Cottone, Lucia
RA   Jorgensen, Mette
RA   Drewry, David Harold
RA   Zuercher, William J.
RA   Turlais, Fabrice
RA   Ye, Hong-Tao
RA   Leite, Ana P.
RA   Smith, James A.
RA   Leithner, Andreas
RA   Moller, Peter
RA   Bruderlein, Silke
RA   Guppy, Naomi
RA   Amary, Fernanda
RA   Tirabosco, Roberto
RA   Strauss, Sandra J.
RA   Pillay, Nischalan
RA   Flanagan, Adrienne Margaret
RT   "EGFR inhibitors identified as a potential treatment for chordoma in a
RT   focused compound screen.";
RL   J. Pathol. 239:320-334(2016).
//
RX   PubMed=21253487; DOI=10.1155/2010/630129; PMCID=PMC3022207;
RA   Bruderlein, Silke
RA   Sommer, Joshua B.
RA   Meltzer, Paul S.
RA   Li, Su-Feng
RA   Osada, Takuya
RA   Ng, David
RA   Moller, Peter
RA   Alcorta, David A.
RA   Kelley, Michael J.
RT   "Molecular characterization of putative chordoma cell lines.";
RL   Sarcoma 2010:630129.1-630129.14(2010).
//
RX   PubMed=28835717; DOI=10.1038/s41598-017-10044-3; PMCID=PMC5569021;
RA   Bosotti, Roberta
RA   Magnaghi, Paola
RA   Di Bella, Sebastiano
RA   Cozzi, Liviana
RA   Cusi, Carlo
RA   Bozzi, Fabio
RA   Beltrami, Nicola
RA   Carapezza, Giovanni
RA   Ballinari, Dario
RA   Amboldi, Nadia
RA   Lupi, Rosita
RA   Somaschini, Alessio
RA   Raddrizzani, Laura
RA   Salom, Barbara
RA   Galvani, Arturo
RA   Stacchiotti, Silvia
RA   Tamborini, Elena
RA   Isacchi, Antonella
RT   "Establishment and genomic characterization of the new chordoma cell
RT   line Chor-IN-1.";
RL   Sci. Rep. 7:9226.1-9226.14(2017).
//