Cellosaurus cell line LNCaP-CL1-GFP (CVCL

Cellosaurus LNCaP-CL1-GFP (CVCL_4924)

Cross-references
Cell line name	LNCaP-CL1-GFP
Synonyms	CL1-GFP
Accession	CVCL_4924
Resource Identification Initiative	To cite this cell line use: LNCaP-CL1-GFP (RRID:CVCL_4924)
Comments	Population: Caucasian. Characteristics: Androgen-independent. Has highly locally invasive and metastatic properties (from parent cell line). Genetic integration: Method=Transfection; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein). Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations	Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line). Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_3872 (LNCaP-CL1)
Sex of cell	Male
Age at sampling	50Y
Category	Cancer cell line
Publications	PubMed=10992426; DOI=10.1016/S0022-5347(05)67210-2 Belur Janakray Patel, Allan Jonathan Pantuck, Amnon Zisman, Ke-Hung Tsui, Sun H. Paik, Randy Caliliw, Scott Sheriff, Lily Wu, Jean B. deKernion, Cho-Lea Tso, Arie S. Belldegrun; CL1-GFP: an androgen independent metastatic tumor model for prostate cancer. J. Urol. 164:1420-1425(2000)
Cell line databases/resources	cancercelllines; CVCL_4924
Encyclopedic resources	Wikidata; Q54902833
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	23