Cellosaurus cell line DuPro-1 (CVCL

Cellosaurus DuPro-1 (CVCL_4738)

Cross-references
Cell line name	DuPro-1
Synonyms	DuPro; DUPRO
Accession	CVCL_4738
Resource Identification Initiative	To cite this cell line use: DuPro-1 (RRID:CVCL_4738)
Comments	Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=14518029; PubMed=20143388). Originally thought to originate from the metastasis in the left supraclavicular lymph node of a 58 year old patient with advanced prostate adenocarcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00189. Population: Caucasian. Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (PubMed=8510267).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0035 (PC-3)
Sex of cell	Male
Age at sampling	62Y
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=1875519; DOI=10.1016/S0022-5347(17)37960-0 Gingrich J.R., Tucker J.A., Walther P.J., Day J.W., Poulton S.H.M., Webb K.S. Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1). J. Urol. 146:915-919(1991) PubMed=8510267; DOI=10.1016/S0022-5347(17)35458-7 Effert P.J., McCoy R.H., Walther P.J., Liu E.T.-B. p53 gene alterations in human prostate carcinoma. J. Urol. 150:257-261(1993) PubMed=14518029; DOI=10.1002/pros.10290 van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S. Molecular characterization of human prostate carcinoma cell lines. Prostate 57:205-225(2003) PubMed=15643172; DOI=10.1097/01.ju.0000141580.30910.57 Sobel R.E., Sadar M.D. Cell lines used in prostate cancer research: a compendium of old and new lines -- part 1. J. Urol. 173:342-359(2005) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Cell line databases/resources	cancercelllines; CVCL_4738
Anatomy/cell type resources	BTO; BTO_0004186
Biological sample resources	BioSample; SAMN03151892
Chemistry resources	ChEMBL-Cells; CHEMBL3307488 ChEMBL-Targets; CHEMBL614289 PubChem_Cell_line; CVCL_4738
Encyclopedic resources	Wikidata; Q27972077
Polymorphism and mutation databases	IARC_TP53; 2303
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	30