ID   DuPro-1
AC   CVCL_4738
DR   BTO; BTO:0004186
DR   BioSample; SAMN03151892
DR   cancercelllines; CVCL_4738
DR   ChEMBL-Cells; CHEMBL3307488
DR   ChEMBL-Targets; CHEMBL614289
DR   IARC_TP53; 2303
DR   PubChem_Cell_line; CVCL_4738
DR   Wikidata; Q27972077
RX   PubMed=1875519;
RX   PubMed=8510267;
RX   PubMed=14518029;
RX   PubMed=15643172;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=14518029; PubMed=20143388). Originally thought to originate from the metastasis in the left supraclavicular lymph node of a 58 year old patient with advanced prostate adenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00189.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (PubMed=8510267).
CC   Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0035 ! PC-3
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 28
RX   PubMed=1875519; DOI=10.1016/S0022-5347(17)37960-0;
RA   Gingrich J.R., Tucker J.A., Walther P.J., Day J.W., Poulton S.H.M.,
RA   Webb K.S.;
RT   "Establishment and characterization of a new human prostatic carcinoma
RT   cell line (DuPro-1).";
RL   J. Urol. 146:915-919(1991).
RX   PubMed=8510267; DOI=10.1016/S0022-5347(17)35458-7;
RA   Effert P.J., McCoy R.H., Walther P.J., Liu E.T.-B.;
RT   "p53 gene alterations in human prostate carcinoma.";
RL   J. Urol. 150:257-261(1993).
RX   PubMed=14518029; DOI=10.1002/pros.10290;
RA   van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U.,
RA   Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.;
RT   "Molecular characterization of human prostate carcinoma cell lines.";
RL   Prostate 57:205-225(2003).
RX   PubMed=15643172; DOI=10.1097/01.ju.0000141580.30910.57;
RA   Sobel R.E., Sadar M.D.;
RT   "Cell lines used in prostate cancer research: a compendium of old and
RT   new lines -- part 1.";
RL   J. Urol. 173:342-359(2005).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).