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Cellosaurus ALVA-55 (CVCL_4736)

[Text version]
Cell line name ALVA-55
Synonyms ALVA55; American Lake VA-55
Accession CVCL_4736
Resource Identification Initiative To cite this cell line use: ALVA-55 (RRID:CVCL_4736)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=14518029; PubMed=20143388). Originally thought to originate from the lymph node metastasis in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00175.
Population: Caucasian.
Doubling time: 22 hours (PubMed=8561862).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O
Mehta P.P., Lokeshwar B.L., Schiller P.C., Bendix M.V., Ostenson R.C., Howard G.A., Roos B.A.
Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP.
Mol. Carcinog. 15:18-32(1996)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4736
Biological sample resources BioSample; SAMN03151891
Encyclopedic resources Wikidata; Q54749381
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25