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Cellosaurus ALVA-55 (CVCL_4736)

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Cell line name ALVA-55
Synonyms ALVA55; American Lake VA-55
Accession CVCL_4736
Resource Identification Initiative To cite this cell line use: ALVA-55 (RRID:CVCL_4736)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=14518029; PubMed=20143388). Originally thought to originate from the lymph node metastasis in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00175.
Population: Caucasian.
Doubling time: 22 hours (PubMed=8561862).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O
Parmender P. Mehta, Balakrishna L. Lokeshwar, Paul C. Schiller, Marcelo V. Bendix, Richard C. Ostenson, Guy A. Howard, Bernard A. Roos;
Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP.
Mol. Carcinog. 15:18-32(1996)

PubMed=14518029; DOI=10.1002/pros.10290
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Widya U. Johannes, E. Erin Smith, Heidi L. Miller, Steven K. Nordeen, Gary J. Miller, M. Scott Lucia;
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4736
Biological sample resources BioSample; SAMN03151891
Encyclopedic resources Wikidata; Q54749381
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27