ID   ALVA-55
AC   CVCL_4736
SY   ALVA55; American Lake VA-55
DR   BioSample; SAMN03151891
DR   cancercelllines; CVCL_4736
DR   Wikidata; Q54749381
RX   PubMed=8561862;
RX   PubMed=14518029;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=14518029; PubMed=20143388). Originally thought to originate from the lymph node metastasis in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00175.
CC   Population: Caucasian.
CC   Doubling time: 22 hours (PubMed=8561862).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0035 ! PC-3
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 27
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RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=14518029; DOI=10.1002/pros.10290;
RA   van Bokhoven, Adrie
RA   Varella-Garcia, Marileila
RA   Korch, Christopher T.
RA   Johannes, Widya U.
RA   Smith, E. Erin
RA   Miller, Heidi L.
RA   Nordeen, Steven K.
RA   Miller, Gary J.
RA   Lucia, Marshall Scott
RT   "Molecular characterization of human prostate carcinoma cell lines.";
RL   Prostate 57:205-225(2003).
//
RX   PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O;
RA   Mehta, Parmender P.
RA   Lokeshwar, Balakrishna L.
RA   Schiller, Paul C.
RA   Bendix, Marcelo Vianna
RA   Ostenson, Richard C.
RA   Howard, Guy A.
RA   Roos, Bernard Allen
RT   "Gap-junctional communication in normal and neoplastic prostate
RT   epithelial cells and its regulation by cAMP.";
RL   Mol. Carcinog. 15:18-32(1996).
//