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Cellosaurus THP-6 (CVCL_4686)

[Text version]
Cell line name THP-6
Synonyms Tohoku Hospital Pediatrics-6
Accession CVCL_4686
Resource Identification Initiative To cite this cell line use: THP-6 (RRID:CVCL_4686)
Comments Population: Japanese.
Doubling time: 24 hours (PubMed=2954268).
Microsatellite instability: Instable (MSI) (PubMed=10739008; PubMed=11226526).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
Publications

PubMed=2954268; DOI=10.1620/tjem.151.283
Masayoshi Minegishi, Shigeru Tsuchiya, Naoko Minegishi, Tasuke Konno;
Establishment of five human malignant non-T lymphoid cell lines and mixed lymphocyte-tumor reaction.
Tohoku J. Exp. Med. 151:283-292(1987)

PubMed=3130528; DOI=10.1016/0145-2126(88)90140-3
Masayoshi Minegishi, Shigeru Tsuchiya, Naoko Minegishi, Osamu Yoshie, Masataka Nakamura, Tasuke Konno;
Characterization of a precursor T-cell line (THP-6) with rearranged T-cell receptor beta chain gene.
Leuk. Res. 12:227-232(1988)

PubMed=8558913
S. Morita, S. Tsuchiya, Hiromi Fujie, Masayuki Itano, Yoshiyuki Ohashi, Masayoshi Minegishi, Masue Imaizumi, M. Endo, Nagako Takano, Tasuke Konno;
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Machiko Kawamura, Hiroaki Ohnishi, Shu-Xia Guo, Xiao-Ming Sheng, Masayoshi Minegishi, Ryoji Hanada, Keizo Horibe, Teruaki Hongo, Yasuhiko Kaneko, Fumio Bessho, Masayoshi Yanagisawa ...Show all 13 authors... , Takao Sekiya, Yasuhide Hayashi; Show fewer authors
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=15472075; DOI=10.1126/science.1102160
Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris 4th, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen Charles Blacklow, Alfred Thomas Look, Jon Christopher Aster;
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4686
Anatomy/cell type resources BTO; BTO_0004926
Encyclopedic resources Wikidata; Q54972355
Polymorphism and mutation databases Cosmic; 721719
Cosmic; 801718
Cosmic; 998732
Cosmic; 1037684
Cosmic; 1375584
IARC_TP53; 10574
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number19