ID   THP-6
AC   CVCL_4686
SY   Tohoku Hospital Pediatrics-6
DR   BTO; BTO:0004926
DR   cancercelllines; CVCL_4686
DR   Cosmic; 721719
DR   Cosmic; 801718
DR   Cosmic; 998732
DR   Cosmic; 1037684
DR   Cosmic; 1375584
DR   IARC_TP53; 10574
DR   Wikidata; Q54972355
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2954268;
RX   PubMed=3130528;
RX   PubMed=8558913;
RX   PubMed=10071127;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=15472075;
CC   Population: Japanese.
CC   Doubling time: 24 hours (PubMed=2954268).
CC   Microsatellite instability: Instable (MSI) (PubMed=10739008; PubMed=11226526).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=10071127).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=10071127).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=10071127).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   6Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 18
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=2954268; DOI=10.1620/tjem.151.283;
RA   Minegishi M., Tsuchiya S., Minegishi N., Konno T.;
RT   "Establishment of five human malignant non-T lymphoid cell lines and
RT   mixed lymphocyte-tumor reaction.";
RL   Tohoku J. Exp. Med. 151:283-292(1987).
//
RX   PubMed=3130528; DOI=10.1016/0145-2126(88)90140-3;
RA   Minegishi M., Tsuchiya S., Minegishi N., Yoshie O., Nakamura M.,
RA   Konno T.;
RT   "Characterization of a precursor T-cell line (THP-6) with rearranged
RT   T-cell receptor beta chain gene.";
RL   Leuk. Res. 12:227-232(1988).
//
RX   PubMed=8558913;
RA   Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M.,
RA   Imaizumi M., Endo M., Takano N., Konno T.;
RT   "Cell surface c-kit receptors in human leukemia cell lines and
RT   pediatric leukemia: selective preservation of c-kit expression on
RT   megakaryoblastic cell lines during adaptation to in vitro culture.";
RL   Leukemia 10:102-105(1996).
//
RX   PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5;
RA   Kawamura M., Ohnishi H., Guo S.X., Sheng X.-M., Minegishi M.,
RA   Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M.,
RA   Sekiya T., Hayashi Y.;
RT   "Alterations of the p53, p21, p16, p15 and RAS genes in childhood
RT   T-cell acute lymphoblastic leukemia.";
RL   Leuk. Res. 23:115-126(1999).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Corrigendum to: Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24
RT   (2000),255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=15472075; DOI=10.1126/science.1102160;
RA   Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B.,
RA   Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.;
RT   "Activating mutations of NOTCH1 in human T cell acute lymphoblastic
RT   leukemia.";
RL   Science 306:269-271(2004).
//