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Cellosaurus H4-II (CVCL_4623)

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Cell line name H4-II
Synonyms H4II; H-35tc2; Reuber-H-35 hepatoma tissue culture 2; Reuber H-35 tc2; Reuber H35 tc2; H-35 Reuber tc2; H35 Reuber tc2; RH-35 tc2; RH35 tc2; H-35 tc2; H35 tc2
Accession CVCL_4623
Resource Identification Initiative To cite this cell line use: H4-II (RRID:CVCL_4623)
Comments Characteristics: Directly derived from the Reuber hepatoma.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Rat hepatocellular carcinoma (NCIt: C60416)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: AxC; RS=RS_0000369.
Hierarchy Children:
CVCL_0284 (H4-II-E)CVCL_E1JW (HyCyte H4-II KO-rInsrr)CVCL_F4SY (HyCyte H4-II stable cell line for rInsrr overexpression)
Originate from same individual CVCL_X358 ! H4AzC2
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=194696; DOI=10.1111/j.1365-2184.1977.tb00291.x
Martin John Evans, Charles J. Kovacs;
Properties of the H-4-II-E tumor cell system. I. Growth and cell proliferation kinetics of an experimental hepatoma.
Cell Tissue Kinet. 10:233-243(1977)

PubMed=115836; DOI=10.1093/jaoac/62.4.904
June A. Bradlaw, James L. Casterline Jr.;
Induction of enzyme activity in cell culture: a rapid screen for detection of planar polychlorinated organic compounds.
J. Assoc. Off. Anal. Chem. 62:904-916(1979)

Cross-references
Cell line collections (Providers) CLS; 305210
ECACC; 89042702
Cell line databases/resources CLO; CLO_0003602
CLDB; cl1549
Encyclopedic resources Wikidata; Q54872157
Entry history
Entry creation04-Apr-2012
Last entry update27-Nov-2025
Version number15