Cellosaurus logo
expasy logo

Cellosaurus IB3-1/C38 (CVCL_4462)

[Text][XML][JSON]
Cell line name IB3-1/C38
Synonyms C38
Accession CVCL_4462
Resource Identification Initiative To cite this cell line use: IB3-1/C38 (RRID:CVCL_4462)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1884; CFTR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: Ad12-SV40 hybrid virus.
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0338 (IB3-1)
Sex of cell Male
Age at sampling 7Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-2779

Markers:
AmelogeninX
CSF1PO10,11
D5S81811,12,13
D7S82011,12
D13S3178,12,13
D16S5399,11
TH018,9.3
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=1380129; DOI=10.1038/358581a0
Marie Egan, Terence R. Flotte, Sandra A. Afione, Rikki Solow, Pamela L. Zeitlin, Barrie J. Carter, William B. Guggino;
Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.
Nature 358:581-584(1992)

PubMed=7679117; DOI=10.1016/S0021-9258(18)53762-5
Terence R. Flotte, Sandra A. Afione, Rikki Solow, Mitchell L. Drumm, Diane Markakis, William B. Guggino, Pamela L. Zeitlin, Barrie J. Carter;
Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter.
J. Biol. Chem. 268:3781-3790(1993)

PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200; PMCID=PMC2444007
Charlotte Andersson, M. Rabie Al-Turkmani, Juanito E. Savaille, Ragheed Alturkmani, Waddah Katrangi, Joanne E. Cluette-Brown, Munir M. Zaman, Michael Laposata, Steven D. Freedman;
Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism.
J. Lipid Res. 49:1692-1700(2008)

Cross-references
Cell line collections (Providers) ATCC; CRL-2779 - Discontinued
ATCC; JHU-54 - Discontinued
Cell line databases/resources CLO; CLO_0002118
Anatomy/cell type resources BTO; BTO_0004447
Biological sample resources BioSample; SAMN03471787
Encyclopedic resources Wikidata; Q54897164
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number15