Cellosaurus logo
expasy logo

Cellosaurus IIICF-E6E7/C4 (CVCL_4411)

[Text version]
Cell line name IIICF-E6E7/C4
Accession CVCL_4411
Resource Identification Initiative To cite this cell line use: IIICF-E6E7/C4 (RRID:CVCL_4411)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0049 but was never intended to be distributed.
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4415 (IIICF/c)
Sex of cell Female
Age at sampling 30-40Y
Category Transformed cell line
Publications

PubMed=22829774; DOI=10.1371/journal.pgen.1002772; PMCID=PMC3400581
Courtney A. Lovejoy, Wen-Di Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H.J. Petrini, Patricia A. Sung, Maria Jasin, Joseph Rosenbluh ...Show all 25 authors... , Yaara Zwang, Barbara A. Weir, Charlie Hatton, Elena V. Ivanova, Laura E. MacConaill, Megan Hanna, William Chun Hahn, Neal F. Lue, Roger Robert Reddel, Yu-Chen Jiao, Kenneth Wayne Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Alan K. Meeker; Show fewer authors
ALT Starr Cancer Consortium
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS Genet. 8:e1002772.1-e1002772.16(2012)

Cross-references
Encyclopedic resources Wikidata; Q54897429
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number18