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Cellosaurus IIICF-E6E7/C4 (CVCL_4411)

[Text version]
Cell line name IIICF-E6E7/C4
Accession CVCL_4411
Resource Identification Initiative To cite this cell line use: IIICF-E6E7/C4 (RRID:CVCL_4411)
Comments Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0049 but was never intended to be distributed.
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4415 (IIICF/c)
Sex of cell Female
Age at sampling 30-40Y
Category Transformed cell line
Publications

PubMed=22829774; DOI=10.1371/journal.pgen.1002772
Lovejoy C.A., Li W.-D., Reisenweber S., Thongthip S., Bruno J., de Lange T., De S., Petrini J.H.J., Sung P.A., Jasin M., Rosenbluh J., Zwang Y., Weir B.A., Hatton C., Ivanova E.V., MacConaill L.E., Hanna M., Hahn W.C., Lue N.F., Reddel R.R., Jiao Y.-C., Kinzler K.W., Vogelstein B., Papadopoulos N., Meeker A.K.
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS Genet. 8:E1002772-E1002772(2012)

Cross-references
Encyclopedic resources Wikidata; Q54897429
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number16