ID   IIICF-E6E7/C4
AC   CVCL_4411
DR   Wikidata; Q54897429
RX   PubMed=22829774;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0049 but was never intended to be distributed.
CC   Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4415 ! IIICF/c
SX   Female
AG   30-40Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 18
//
RX   PubMed=22829774; DOI=10.1371/journal.pgen.1002772; PMCID=PMC3400581;
RA   Lovejoy C.A., Li W.-D., Reisenweber S., Thongthip S., Bruno J.,
RA   de Lange T., De S., Petrini J.H.J., Sung P.A., Jasin M., Rosenbluh J.,
RA   Zwang Y., Weir B.A., Hatton C., Ivanova E.V., MacConaill L.E., Hanna M.,
RA   Hahn W.C., Lue N.F., Reddel R.R., Jiao Y.-C., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N., Meeker A.K.;
RG   ALT Starr Cancer Consortium;
RT   "Loss of ATRX, genome instability, and an altered DNA damage response
RT   are hallmarks of the alternative lengthening of telomeres pathway.";
RL   PLoS Genet. 8:e1002772.1-e1002772.16(2012).
//