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Cellosaurus SU-DHL-7 (CVCL_4380)

[Text version]
Cell line name SU-DHL-7
Synonyms SUDHL7; SUDHL-7; SuDHL 7; Stanford University-Diffuse Histiocytic Lymphoma-7; DHL-7; DHL7
Accession CVCL_4380
Resource Identification Initiative To cite this cell line use: SU-DHL-7 (RRID:CVCL_4380)
Comments Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00557.
Doubling time: ~50 hours (DSMZ=ACC-903).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Caution: Was reported in Cellosaurus and the ICLAC Register (from 2018 to early 2022) to be a SU-DHL-8 contaminated cell line but there seem to have been an issue with the sample tested. DSMZ has obtained original stock from Epstein A.L. and SU-DHL-7 is a genuine non-problematic cell line.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-903

Markers:
AmelogeninX
CSF1PO10,12
D2S133816,20
D3S135816
D5S81811,13
D7S82010,11
D8S117912,14
D13S31712,13
D16S5399,12
D18S5114,15
D19S43312,14
D21S1132.2
FGA20,25
Penta D13
Penta E12,15
TH017,9.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=214220; DOI=10.1002/1097-0142(197811)42:5<2379::AID-CNCR2820420539>3.0.CO;2-4
Alan L. Epstein, Ronald Levy, Hun Kim, Werner Henle, Gertrude Szpingier Henle, Henry Seymour Kaplan;
Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.
Cancer 42:2379-2391(1978)

PubMed=83902; DOI=10.1002/1097-0142(197901)43:1<1::AID-CNCR2820430102>3.0.CO;2-M
Henry Seymour Kaplan, Robert S. Goodenow, Suzanne Gartner, Marcia M. Bieber;
Biology and virology of the human malignant lymphomas: 1st Milford D Schulz lecture.
Cancer 43:1-24(1979)

PubMed=371794
Alan L. Epstein, Henry Seymour Kaplan;
Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines.
Cancer Res. 39:1748-1759(1979)

PubMed=3881165; DOI=10.1016/0165-4608(85)90186-4
Barbara Kaiser-McCaw Hecht, Alan L. Epstein, Carol S. Berger, Henry Seymour Kaplan, Frederick Hecht;
Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.
Cancer Genet. Cytogenet. 14:205-218(1985)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Reiner Siebert, Christoph P. Willers, Alexander Schramm, Alexander Fossa, Irina M. Gana Dresen, Michael J. Uppenkamp, Mohammad Resa Nowrousian, Siegfried Seeber, Bertram Opalka;
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Akira Sakai, Catherine Thieblemont, Axel Wellmann, Elaine Sarkin Jaffe, Mark Raffeld;
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058
Cheng Li, Sang-Woo Kim, Deepak Rai, Aswani R. Bolla, Siddharth Adhvaryu, Marsha C. Kinney, Ryan S. Robetorye, Ricardo C.T. Aguiar;
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Michael Richard Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd Robert Golub, Jeffery L. Kutok, Margaret Ann Shipp;
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051
Jenny Zhang, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr Andrzej Mieczkowski, Cherie Dunphy, William Wai-Lap Choi, Wing Yan Au, Gopesh Srivastava, Patricia Lynne Lugar ...Show all 36 authors... , David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher Robert Flowers, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Magdalena B. Czader, Javed Iqbal Gill, Eric Darryl Hsi, Qing-Quan Liu, Alice Fan, Katherine Walsh, Dereje Jima, Lisa L. Smith, Amy J. Johnson, John C. Byrd, Micah Alan Luftig, Ting Ni, Jun Zhu, Amy Chadburn, Shawn Levy, David Brian Dunson, Sandeep S. Dave; Show fewer authors
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

Cross-references
Cell line collections (Providers) DSMZ; ACC-903
Cell line databases/resources cancercelllines; CVCL_4380
DSMZCellDive; ACC-903
Encyclopedic resources Wikidata; Q54970722
Gene expression databases GEO; GSM380148
GEO; GSM552466
GEO; GSM1035335
Polymorphism and mutation databases Cosmic; 850206
Cosmic; 1290018
Cosmic; 1517608
Cosmic; 1541912
Cosmic; 1945193
Cosmic; 2276341
Cosmic; 2361373
Progenetix; CVCL_4380
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number32