Cellosaurus logo
expasy logo

Cellosaurus CHO-xrs-6 (CVCL_4340)

[Text version]
Cell line name CHO-xrs-6
Synonyms CHO-XrS6; CHO-XRS6; CHO XrS6; xrs-6; xrs 6; XrS6; XRS6; xrs6
Accession CVCL_4340
Resource Identification Initiative To cite this cell line use: CHO-xrs-6 (RRID:CVCL_4340)
Comments Characteristics: Sensitive to X-ray. Has a defect in double-strand break rejoining (PubMed=6513971).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Children:
CVCL_4341 (CHO-xrs-6-hamKu80)CVCL_5A41 (CHO-xrs-6C)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6197643; DOI=10.1016/0167-8817(83)90026-3
Penelope Ann Jeggo, Lynn M. Kemp;
X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents.
Mutat. Res. 112:313-327(1983)

PubMed=6513971; DOI=10.1016/0167-8817(84)90037-3
Lynn M. Kemp, Steven G. Sedgwick, Penelope Ann Jeggo;
X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining.
Mutat. Res. 132:189-196(1984)

PubMed=3785270; DOI=10.1016/0167-8817(86)90025-8
Lynn M. Kemp, Penelope Ann Jeggo;
Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line.
Mutat. Res. 166:255-263(1986)

PubMed=2564870; DOI=10.1080/09553008914550651
Julie Denekamp, Gordon Francis Whitmore, Penelope Ann Jeggo;
Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence?
Int. J. Radiat. Biol. 55:605-617(1989)

PubMed=8799130; DOI=10.1073/pnas.93.17.8929; PMCID=PMC38571
Feng Liang, Peter J. Romanienko, David T. Weaver, Penelope Ann Jeggo, Maria Jasin;
Chromosomal double-strand break repair in Ku80-deficient cells.
Proc. Natl. Acad. Sci. U.S.A. 93:8929-8933(1996)

PubMed=9032253; DOI=10.1128/mcb.17.3.1264; PMCID=PMC231851
Belinda K. Singleton, Anne Priestley, Herdis Steingrimsdottir, David Gell, Tracy Blunt, Stephen Philip Jackson, Alan R. Lehmann, Penelope Ann Jeggo;
Molecular and biochemical characterization of xrs mutants defective in Ku80.
Mol. Cell. Biol. 17:1264-1273(1997)

Cross-references
Cell line collections (Providers) ECACC; 92052128
Cell line databases/resources CLO; CLO_0009692
CLDB; cl4784
Anatomy/cell type resources BTO; BTO_0004066
Chemistry resources ChEMBL-Cells; CHEMBL3307295
ChEMBL-Targets; CHEMBL614060
PubChem_Cell_line; CVCL_4340
Encyclopedic resources Wikidata; Q54813132
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number14