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Cellosaurus HBL-5 (CVCL_4219)

[Text version]
Cell line name HBL-5
Accession CVCL_4219
Resource Identification Initiative To cite this cell line use: HBL-5 (RRID:CVCL_4219)
Comments Population: Japanese.
Doubling time: 24 hours (PubMed=2486609); ~48 hours (PubMed=1309680).
Karyotypic information: Near tetraploid karyotype.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5817; IGKV3-20 + HGNC; 37659; RNA28S5; Name(s)=IGKV3-20-RNA28S5, IGKV3-20-RN28S1 (PubMed=24504345).
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (PubMed=9454894; PubMed=12967475).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=2486609
Abe M., Wakawa H.
Establishment and characterization of human Burkitt's lymphoma cell (HBL-5).
Hum. Cell 2:195-196(1989)

PubMed=1309680; DOI=10.1002/1097-0142(19920201)69:3<763::AID-CNCR2820690325>3.0.CO;2-#
Abe M., Tasaki K., Tominaga K., Fukuhara S., Imai S., Osato T., Wakasa H.
Characterization and comparison of two newly established Epstein-Barr virus (EBV)-negative and EBV-positive Burkitt's lymphoma cell lines EBV-negative cell line with a low level of expression of ICAM-1 molecule and EBV-positive cell line with a high level of expression of ICAM-1 molecule.
Cancer 69:763-771(1992)

PubMed=1592367; DOI=10.1002/hon.2900100205
Nakamura N., Suzuki S., Ono N., Tominaga K., Hojo H., Abe M., Wakasa H.
A new monoclonal antibody which binds to the cytoplasm of large cell lymphomas.
Hematol. Oncol. 10:95-104(1992)

PubMed=9454894; DOI=10.3892/ijo.12.1.113
Akasaka T., Akasaka H., Ohno H.
Polymerase chain reaction amplification of long DNA targets: application to analysis of chromosomal translocations in human B-cell tumors.
Int. J. Oncol. 12:113-121(1998)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x
Maesako Y., Uchiyama T., Ohno H.
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Kamimura K., Hojo H., Abe M.
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=24504345; DOI=10.3892/ijo.2014.2291
Kobayashi S., Taki T., Nagoshi H., Chinen Y., Yokokawa Y., Kanegane H., Matsumoto Y., Kuroda J., Horiike S., Nishida K., Taniwaki M.
Identification of novel fusion genes with 28S ribosomal DNA in hematologic malignancies.
Int. J. Oncol. 44:1193-1198(2014)

Cross-references
Anatomy/cell type resources BTO; BTO:0002527
Encyclopedic resources Wikidata; Q54881437
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number22