ID   HBL-5
AC   CVCL_4219
DR   BTO; BTO:0002527
DR   Wikidata; Q54881437
RX   PubMed=1309680;
RX   PubMed=1592367;
RX   PubMed=2486609;
RX   PubMed=9454894;
RX   PubMed=12967475;
RX   PubMed=15028022;
RX   PubMed=24504345;
CC   Population: Japanese.
CC   Doubling time: 24 hours (PubMed=2486609); ~48 hours (PubMed=1309680).
CC   Karyotypic information: Near tetraploid karyotype.
CC   Sequence variation: Gene fusion; HGNC; 5817; IGKV3-20 + HGNC; 37659; RNA28S5; Name(s)=IGKV3-20-RNA28S5, IGKV3-20-RN28S1 (PubMed=24504345).
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (PubMed=9454894; PubMed=12967475).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 22
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RX   PubMed=1309680; DOI=10.1002/1097-0142(19920201)69:3<763::AID-CNCR2820690325>3.0.CO;2-#;
RA   Abe M., Tasaki K., Tominaga K., Fukuhara S., Imai S., Osato T.,
RA   Wakasa H.;
RT   "Characterization and comparison of two newly established Epstein-Barr
RT   virus (EBV)-negative and EBV-positive Burkitt's lymphoma cell lines.
RT   EBV-negative cell line with a low level of expression of ICAM-1
RT   molecule and EBV-positive cell line with a high level of expression of
RT   ICAM-1 molecule.";
RL   Cancer 69:763-771(1992).
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RX   PubMed=1592367; DOI=10.1002/hon.2900100205;
RA   Nakamura N., Suzuki S., Ono N., Tominaga K., Hojo H., Abe M.,
RA   Wakasa H.;
RT   "A new monoclonal antibody which binds to the cytoplasm of large cell
RT   lymphomas.";
RL   Hematol. Oncol. 10:95-104(1992).
//
RX   PubMed=2486609;
RA   Abe M., Wakawa H.;
RT   "Establishment and characterization of human Burkitt's lymphoma cell
RT   (HBL-5).";
RL   Hum. Cell 2:195-196(1989).
//
RX   PubMed=9454894; DOI=10.3892/ijo.12.1.113;
RA   Akasaka T., Akasaka H., Ohno H.;
RT   "Polymerase chain reaction amplification of long DNA targets:
RT   application to analysis of chromosomal translocations in human B-cell
RT   tumors.";
RL   Int. J. Oncol. 12:113-121(1998).
//
RX   PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x;
RA   Maesako Y., Uchiyama T., Ohno H.;
RT   "Comparison of gene expression profiles of lymphoma cell lines from
RT   transformed follicular lymphoma, Burkitt's lymphoma and de novo
RT   diffuse large B-cell lymphoma.";
RL   Cancer Sci. 94:774-781(2003).
//
RX   PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x;
RA   Kamimura K., Hojo H., Abe M.;
RT   "Characterization of expression of protein kinase C isozymes in human
RT   B-cell lymphoma: relationship between its expression and prognosis.";
RL   Pathol. Int. 54:224-230(2004).
//
RX   PubMed=24504345; DOI=10.3892/ijo.2014.2291;
RA   Kobayashi S., Taki T., Nagoshi H., Chinen Y., Yokokawa Y.,
RA   Kanegane H., Matsumoto Y., Kuroda J., Horiike S., Nishida K.,
RA   Taniwaki M.;
RT   "Identification of novel fusion genes with 28S ribosomal DNA in
RT   hematologic malignancies.";
RL   Int. J. Oncol. 44:1193-1198(2014).
//