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Cellosaurus HBL-1 [Human diffuse large B-cell lymphoma] (CVCL_4213)

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Cell line name HBL-1 [Human diffuse large B-cell lymphoma]
Synonyms HBL1
Accession CVCL_4213
Resource Identification Initiative To cite this cell line use: HBL-1 [Human diffuse large B-cell lymphoma] (RRID:CVCL_4213)
Comments Population: Japanese.
Doubling time: ~48 hours (PubMed=3338018).
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1699; CD79B; Simple; p.Tyr196Phe (c.587A>T); Zygosity=Heterozygous (PubMed=20054396).
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=21179087).
Disease Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=2854303; DOI=10.1620/tjem.156.319
Yoshihiro Nozawa, Masafumi Abe, Haruki Wakasa, Hitoshi Ohno, Shiro Fukuhara, Toshibumi Kinoshita, Toyoro Osato;
Establishment and characterization of an Epstein-Barr virus negative B-cell lymphoma cell line and successful heterotransplantation.
Tohoku J. Exp. Med. 156:319-330(1988)

PubMed=3338018; DOI=10.1002/1097-0142(19880201)61:3<483::AID-CNCR2820610313>3.0.CO;2-L
Masafumi Abe, Yoshihiro Nozawa, Haruki Wakasa, Hitoshi Ohno, Shiro Fukuhara;
Characterization and comparison of two newly established Epstein-Barr virus-negative lymphoma B-cell lines. Surface markers, growth characteristics, cytogenetics, and transplantability.
Cancer 61:483-490(1988)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Katsuhito Kamimura, Hiroshi Hojo, Masafumi Abe;
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535
R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul Bernard Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yan-Dan Yang, Wei-Hong Xu, Arthur L. Shaffer 3rd, George Wright ...Show all 37 authors... , Wen-Ming Xiao, John I. Powell, Jian-Kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans-Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Susan Keen Pierce, Louis Michael Staudt; Show fewer authors
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature 463:88-92(2010)

PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568
Vu N. Ngo, Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wen-Ming Xiao, Kian-Huat Lim, Holger Kohlhammer, Wei-Hong Xu, Yan-Dan Yang, Hong Zhao, Arthur L. Shaffer 3rd, Paul Bernard Romesser, George Wright ...Show all 31 authors... , John I. Powell, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Louis Michael Staudt; Show fewer authors
Oncogenically active MYD88 mutations in human lymphoma.
Nature 470:115-119(2011)

PubMed=23257783; DOI=10.1038/leu.2012.367
Soren-Sebastian Wenzel, Michael Grau, Cory Mavis, Stephan Hailfinger, Annette Wolf, Hannelore Madle, George Deeb, Bernd Dorken, Margot Thome, Peter Lenz, Stefan Dirnhofer, Francisco Javier Hernandez-Ilizaliturri, Alexandar Tzankov ...Show all 14 authors... , Georg Lenz; Show fewer authors
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)

PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717
Joseph D. Dekker, Daechan Park, Arthur L. Shaffer 3rd, Holger Kohlhammer, Wei Deng, Bum-Kyu Lee, Gregory C. Ippolito, George Georgiou, Vishwanath R. Iyer, Louis Michael Staudt, Haley O. Tucker;
Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.
Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016)

PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470
Wei Liu, Juan Chen, Archito T. Tamayo, Chang-Geng Ruan, Li Li, Shou-Hao Zhou, Chan Shen, Ken H. Young, Jason Westin, Richard E. Davis, Shi-Min Hu, L. Jeffrey Medeiros, Richard Joseph Ford Jr. ...Show all 14 authors... , Lan V. Pham; Show fewer authors
Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.
Oncotarget 9:346-360(2018)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis, Ken H. Young, L. Jeffrey Medeiros ...Show all 17 authors... , Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020
Chang-Ju Qu, Kranthi Kunkalla, Amineh Vaghefi, John K. Frederiksen, Ya-Dong Liu, Jennifer R. Chapman, Marzenna Blonska, Leon Bernal-Mizrachi, Juan Pablo Alderuccio, Izidore S. Lossos, Ralf Landgraf, Francisco Vega-Vazquez;
Smoothened stabilizes and protects TRAF6 from degradation: a novel non-canonical role of smoothened with implications in lymphoma biology.
Cancer Lett. 436:149-158(2018)

PubMed=31510952; DOI=10.1186/s12885-019-6129-8; PMCID=PMC6739943
Yasuo Takashima, Takeshi Yoshimura, Yuichiro Kano, Azusa Hayano, Hiroaki Hondoh, Kazuhiro Ikenaka, Ryuya Yamanaka;
Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells.
BMC Cancer 19:910.1-910.11(2019)

Cross-references
Cell line databases/resources CLO; CLO_0037256
cancercelllines; CVCL_4213
Anatomy/cell type resources BTO; BTO_0002522
CRISP screens repositories BioGRID_ORCS_Cell_line; 747
Encyclopedic resources Wikidata; Q54881426
Experimental variables resources EFO; EFO_0022408
Gene expression databases GEO; GSM1035338
GEO; GSM1059804
GEO; GSM1374489
GEO; GSM1890017
GEO; GSM1890018
GEO; GSM1890019
GEO; GSM1890020
GEO; GSM2037050
GEO; GSM2037051
Polymorphism and mutation databases Cosmic; 1486586
Cosmic; 1487545
Cosmic; 1517652
Cosmic; 2129634
Cosmic; 2437308
Progenetix; CVCL_4213
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number29