ID HBL-1 [Human diffuse large B-cell lymphoma] AC CVCL_4213 SY HBL1 DR BTO; BTO_0002522 DR CLO; CLO_0037256 DR EFO; EFO_0022408 DR BioGRID_ORCS_Cell_line; 747 DR cancercelllines; CVCL_4213 DR Cosmic; 1486586 DR Cosmic; 1487545 DR Cosmic; 1517652 DR Cosmic; 2129634 DR Cosmic; 2437308 DR GEO; GSM1035338 DR GEO; GSM1059804 DR GEO; GSM1374489 DR GEO; GSM1890017 DR GEO; GSM1890018 DR GEO; GSM1890019 DR GEO; GSM1890020 DR GEO; GSM2037050 DR GEO; GSM2037051 DR Progenetix; CVCL_4213 DR Wikidata; Q54881426 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=2854303; RX PubMed=3338018; RX PubMed=8558920; RX PubMed=15028022; RX PubMed=20054396; RX PubMed=21179087; RX PubMed=23257783; RX PubMed=26787899; RX PubMed=29416618; RX PubMed=29666304; RX PubMed=30165192; RX PubMed=31510952; CC Population: Japanese. CC Doubling time: ~48 hours (PubMed=3338018). CC Karyotypic information: Has lost chromosome Y. CC Sequence variation: Mutation; HGNC; HGNC:1699; CD79B; Simple; p.Tyr196Phe (c.587A>T); Zygosity=Heterozygous (PubMed=20054396). CC Sequence variation: Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=21179087). CC Omics: Transcriptomics; Microarray. CC Omics: Variations; Array-based CGH. CC Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. DI NCIt; C36081; Diffuse large B-cell lymphoma activated B-cell type DI ORDO; Orphanet_544; Diffuse large B-cell lymphoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 65Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 29 // RX PubMed=2854303; DOI=10.1620/tjem.156.319; RA Nozawa, Yoshihiro RA Abe, Masafumi RA Wakasa, Haruki RA Ohno, Hitoshi RA Fukuhara, Shiro RA Kinoshita, Toshibumi RA Osato, Toyoro RT "Establishment and characterization of an Epstein-Barr virus negative RT B-cell lymphoma cell line and successful heterotransplantation."; RL Tohoku J. Exp. Med. 156:319-330(1988). // RX PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020; RA Qu, Chang-Ju RA Kunkalla, Kranthi RA Vaghefi, Amineh RA Frederiksen, John K. RA Liu, Ya-Dong RA Chapman, Jennifer Rose RA Blonska, Marzenna RA Bernal-Mizrachi, Leon RA Alderuccio, Juan Pablo RA Lossos, Izidore S. RA Landgraf, Ralf RA Vega-Vazquez, Francisco RT "Smoothened stabilizes and protects TRAF6 from degradation: a novel RT non-canonical role of smoothened with implications in lymphoma RT biology."; RL Cancer Lett. 436:149-158(2018). // RX PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568; RA Ngo, Vu N. RA Young, Ryan M. RA Schmitz, Roland RA Jhavar, Sameer RA Xiao, Wen-Ming RA Lim, Kian-Huat RA Kohlhammer, Holger RA Xu, Wei-Hong RA Yang, Yan-Dan RA Zhao, Hong RA Shaffer, Arthur L. 3rd RA Romesser, Paul Bernard RA Wright, George RA Powell, John I. RA Rosenwald, Andreas RA Muller-Hermelink, Hans-Konrad RA Ott, German RA Gascoyne, Randy D. RA Connors, Joseph M. RA Rimsza, Lisa M. RA Campo, Elias RA Jaffe, Elaine Sarkin RA Delabie, Jan RA Smeland, Erlend Bremertun RA Fisher, Richard I. RA Braziel, Rita Merle RA Tubbs, Raymond Roy RA Cook, James R. RA Weisenburger, Dennis D. RA Chan, Wing-Chung RA Staudt, Louis Michael RT "Oncogenically active MYD88 mutations in human lymphoma."; RL Nature 470:115-119(2011). // RX PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717; RA Dekker, Joseph D. RA Park, Daechan RA Shaffer, Arthur L. 3rd RA Kohlhammer, Holger RA Deng, Wei RA Lee, Bum-Kyu RA Ippolito, Gregory C. RA Georgiou, George RA Iyer, Vishwanath R. RA Staudt, Louis Michael RA Tucker, Haley O. RT "Subtype-specific addiction of the activated B-cell subset of diffuse RT large B-cell lymphoma to FOXP1."; RL Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016). // RX PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535; RA Davis, R. Eric RA Ngo, Vu N. RA Lenz, Georg RA Tolar, Pavel RA Young, Ryan M. RA Romesser, Paul Bernard RA Kohlhammer, Holger RA Lamy, Laurence RA Zhao, Hong RA Yang, Yan-Dan RA Xu, Wei-Hong RA Shaffer, Arthur L. 3rd RA Wright, George RA Xiao, Wen-Ming RA Powell, John I. RA Jiang, Jian-Kang RA Thomas, Craig J. RA Rosenwald, Andreas RA Ott, German RA Muller-Hermelink, Hans-Konrad RA Gascoyne, Randy D. RA Connors, Joseph M. RA Johnson, Nathalie A. RA Rimsza, Lisa M. RA Campo, Elias RA Jaffe, Elaine Sarkin RA Wilson, Wyndham H. RA Delabie, Jan RA Smeland, Erlend Bremertun RA Fisher, Richard I. RA Braziel, Rita Merle RA Tubbs, Raymond Roy RA Cook, James R. RA Weisenburger, Dennis D. RA Chan, Wing-Chung RA Pierce, Susan Keen RA Staudt, Louis Michael RT "Chronic active B-cell-receptor signalling in diffuse large B-cell RT lymphoma."; RL Nature 463:88-92(2010). // RX PubMed=8558920; RA Dirks, Wilhelm Gerhard RA Zaborski, Margarete RA Jager, Kathrin RA Challier, Cecile RA Shiota, Mami RA Quentmeier, Hilmar RA Drexler, Hans Gunther RT "The (2;5)(p23;q35) translocation in cell lines derived from malignant RT lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines."; RL Leukemia 10:142-149(1996). // RX PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470; RA Liu, Wei RA Chen, Juan RA Tamayo, Archito T. RA Ruan, Chang-Geng RA Li, Li RA Zhou, Shou-Hao RA Shen, Chan RA Young, Ken H. RA Westin, Jason RA Davis, Richard E. RA Hu, Shi-Min RA Medeiros, L. Jeffrey RA Ford, Richard Joseph Jr. RA Pham, Lan V. RT "Preclinical efficacy and biological effects of the oral proteasome RT inhibitor ixazomib in diffuse large B-cell lymphoma."; RL Oncotarget 9:346-360(2018). // RX PubMed=31510952; DOI=10.1186/s12885-019-6129-8; PMCID=PMC6739943; RA Takashima, Yasuo RA Yoshimura, Takeshi RA Kano, Yuichiro RA Hayano, Azusa RA Hondoh, Hiroaki RA Ikenaka, Kazuhiro RA Yamanaka, Ryuya RT "Differential expression of N-linked oligosaccharides in RT methotrexate-resistant primary central nervous system lymphoma RT cells."; RL BMC Cancer 19:910.1-910.11(2019). // RX PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004; RA Pham, Lan V. RA Huang, Sheng-Jian RA Zhang, Hui RA Zhang, Jun RA Bell, Taylor RA Zhou, Shou-Hao RA Pogue, Elizabeth RA Ding, Zhi-Yong RA Lam, Laura RA Westin, Jason RA Davis, R. Eric RA Young, Ken H. RA Medeiros, L. Jeffrey RA Ford, Richard Joseph Jr. RA Nomie, Krystle RA Zhang, Leo RA Wang, Michael RT "Strategic therapeutic targeting to overcome venetoclax resistance in RT aggressive B-cell lymphomas."; RL Clin. Cancer Res. 24:3967-3980(2018). // RX PubMed=23257783; DOI=10.1038/leu.2012.367; RA Wenzel, Soren-Sebastian RA Grau, Michael RA Mavis, Cory RA Hailfinger, Stephan RA Wolf, Annette RA Madle, Hannelore RA Deeb, George RA Dorken, Bernd RA Thome, Margot RA Lenz, Peter RA Dirnhofer, Stefan RA Hernandez-Ilizaliturri, Francisco Javier RA Tzankov, Alexandar RA Lenz, Georg RT "MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma."; RL Leukemia 27:1381-1390(2013). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x; RA Kamimura, Katsuhito RA Hojo, Hiroshi RA Abe, Masafumi RT "Characterization of expression of protein kinase C isozymes in human RT B-cell lymphoma: relationship between its expression and prognosis."; RL Pathol. Int. 54:224-230(2004). // RX PubMed=3338018; DOI=10.1002/1097-0142(19880201)61:3<483::AID-CNCR2820610313>3.0.CO;2-L; RA Abe, Masafumi RA Nozawa, Yoshihiro RA Wakasa, Haruki RA Ohno, Hitoshi RA Fukuhara, Shiro RT "Characterization and comparison of two newly established Epstein-Barr RT virus-negative lymphoma B-cell lines. Surface markers, growth RT characteristics, cytogenetics, and transplantability."; RL Cancer 61:483-490(1988). //