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Cellosaurus FM3Ats C1.T85 (CVCL_4201)

[Text version]
Cell line name FM3Ats C1.T85
Synonyms FM3A tscl.T85 Tsai; FM3A ts85; FM3Ats85; ts85; Ts85
Accession CVCL_4201
Resource Identification Initiative To cite this cell line use: FM3Ats C1.T85 (RRID:CVCL_4201)
Comments Characteristics: Has a thermolabile ubiquitin-like modifier-activating enzyme 1 (Uba1) (PubMed=6327059).
Doubling time: 18 hours (PubMed=6153988).
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/He.
Hierarchy Parent: CVCL_3869 (FM3A)
Children:
CVCL_A5JW (FM3A ts85R-MN3)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=6153988; DOI=10.1016/0014-4827(80)90280-3
Shiro Mita, Hideyo Yasuda, Tohru Marunouchi, S. Ishiko, Masa-atsu Yamada;
A temperature-sensitive mutant of cultured mouse cells defective in chromosome condensation.
Exp. Cell Res. 126:407-416(1980)

PubMed=7284331; DOI=10.1021/bi00518a028
Hideyo Yasuda, Yoh-ichi Matsumoto, Shiro Mita, Tohru Marunouchi, Masa-atsu Yamada;
A mouse temperature-sensitive mutant defective in H1 histone phosphorylation is defective in deoxyribonucleic acid synthesis and chromosome condensation.
Biochemistry 20:4414-4419(1981)

PubMed=6327059; DOI=10.1016/0092-8674(84)90299-x
Daniel J. Finley, Aaron Ciechanover, Alexander Varshavsky;
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
Cell 37:43-55(1984)

PubMed=3049611; DOI=10.1016/S0021-9258(19)37648-3
Richard G. Kulka, Bilha Raboy, Ruth Schuster, Hadas A. Parag, Gill Diamond, Aaron Ciechanover, Menashe Marcus;
A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.
J. Biol. Chem. 263:15726-15731(1988)

PubMed=2156848; DOI=10.1016/S0021-9258(19)39329-9
Quinn Deveraux, Rod Wells, Martin Rechsteiner;
Ubiquitin metabolism in ts85 cells, a mouse carcinoma line that contains a thermolabile ubiquitin activating enzyme.
J. Biol. Chem. 265:6323-6329(1990)

Cross-references
Cell line collections (Providers) ECACC; 87111904
JCRB; JCRB0705
RCB; RCB0033
Cell line databases/resources CLO; CLO_0003371
CLO; CLO_0050960
CLDB; cl1379
Encyclopedic resources Wikidata; Q54835040
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number13