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Cellosaurus DBS-FRhL-2 (CVCL_4160)

[Text version]
Cell line name DBS-FRhL-2
Synonyms DBS-FRHL-2; DBSFRhL-2; DBSFRHL-2; DBSFRhL2; FRhL-2; FrHL-2; FrhL2; Division of Biologics Standards-Fetal Rhesus Lung-2
Accession CVCL_4160
Resource Identification Initiative To cite this cell line use: DBS-FRhL-2 (RRID:CVCL_4160)
Comments Group: Non-human primate cell line.
Group: Patented cell line.
Group: Vaccine production cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-160.
Biotechnology: Was used from 1997 to 1999 for the production of the rhesus rotavirus vaccine-tetravalent (RRV-TV) by Wyeth Laboratories (Trade Name: RotaShield).
Senescence: Senesces at ~74 PDL.
Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Macaca mulatta (Rhesus macaque) (NCBI Taxonomy: 9544)
Sex of cell Male
Age at sampling Fetus
Category Finite cell line
Publications

PubMed=4348695; DOI=10.1007/BF02619056
Roslyn Elizabeth Wallace, Paul John Vasington, John C. Petricciani, Hope Elizabeth Hopps, Douglas E. Lorenz, Zdenek Kadanka;
Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production.
In Vitro 8:323-332(1973)

PubMed=4203458
John C. Petricciani, Roslyn Elizabeth Wallace, Donald W. McCoy;
A comparison of three in vivo assays for cell tumorigenicity.
Cancer Res. 34:105-108(1974)

Patent=US4040905
John C. Petricciani, Hope Elizabeth Hopps, Douglas E. Lorenz, Paul John Vasington, Roslyn Elizabeth Wallace;
Sub-human primate diploid cell lines as substrates for virus vaccine production.
Patent number US4040905, 09-Aug-1977

PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222
Robert J. Hay, Carolyn D. Williams, Marvin L. Macy, Kantharajapura Subbegowda Lavappa;
Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection.
Am. Rev. Respir. Dis. 125:222-232(1982)

Cross-references
Cell line collections (Providers) ATCC; CCL-160 - Discontinued
ATCC; CL-160
ECACC; 89101303
IZSLER; BS CL 215 - Discontinued
Cell line databases/resources CLO; CLO_0002721
CLDB; cl1004
Encyclopedic resources Wikidata; Q54828612
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19