Cellosaurus cell line DBS-FRhL-2 (CVCL

Cellosaurus DBS-FRhL-2 (CVCL_4160)

Cross-references
Cell line name	DBS-FRhL-2
Synonyms	DBS-FRHL-2; DBSFRhL-2; DBSFRHL-2; DBSFRhL2; FRhL-2; FrHL-2; FrhL2; Division of Biologics Standards-Fetal Rhesus Lung-2
Accession	CVCL_4160
Resource Identification Initiative	To cite this cell line use: DBS-FRhL-2 (RRID:CVCL_4160)
Comments	Group: Non-human primate cell line. Group: Patented cell line. Group: Vaccine production cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-160. Biotechnology: Was used from 1997 to 1999 for the production of the rhesus rotavirus vaccine-tetravalent (RRV-TV) by Wyeth Laboratories (Trade Name: RotaShield). Senescence: Senesces at ~74 PDL. Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597. Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin	Macaca mulatta (Rhesus macaque) (NCBI Taxonomy: 9544)
Sex of cell	Male
Age at sampling	Fetus
Category	Finite cell line
Publications	PubMed=4348695; DOI=10.1007/BF02619056 Roslyn Elizabeth Wallace, Paul John Vasington, John C. Petricciani, Hope Elizabeth Hopps, Douglas E. Lorenz, Zdenek Kadanka; Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production. In Vitro 8:323-332(1973) PubMed=4203458 John C. Petricciani, Roslyn Elizabeth Wallace, Donald W. McCoy; A comparison of three in vivo assays for cell tumorigenicity. Cancer Res. 34:105-108(1974) Patent=US4040905 John C. Petricciani, Hope Elizabeth Hopps, Douglas E. Lorenz, Paul John Vasington, Roslyn Elizabeth Wallace; Sub-human primate diploid cell lines as substrates for virus vaccine production. Patent number US4040905, 09-Aug-1977 PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Robert J. Hay, Carolyn D. Williams, Marvin L. Macy, Kantharajapura Subbegowda Lavappa; Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982)
Cell line collections (Providers)	ATCC; CCL-160 - Discontinued ATCC; CL-160 ECACC; 89101303 IZSLER; BS CL 215 - Discontinued
Cell line databases/resources	CLO; CLO_0002721 CLDB; cl1004
Encyclopedic resources	Wikidata; Q54828612
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	19