ID   DBS-FRhL-2
AC   CVCL_4160
SY   DBS-FRHL-2; DBSFRhL-2; DBSFRHL-2; DBSFRhL2; FRhL-2; FrHL-2; FrhL2; Division of Biologics Standards-Fetal Rhesus Lung-2
DR   CLO; CLO_0002721
DR   CLDB; cl1004
DR   ATCC; CL-160
DR   ATCC; CCL-160
DR   ECACC; 89101303
DR   IZSLER; BS CL 215
DR   Wikidata; Q54828612
RX   Patent=US4040905;
RX   PubMed=4203458;
RX   PubMed=4348695;
RX   PubMed=7065527;
CC   Group: Non-human primate cell line.
CC   Group: Patented cell line.
CC   Group: Vaccine production cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-160.
CC   Biotechnology: Was used from 1997 to 1999 for the production of the rhesus rotavirus vaccine-tetravalent (RRV-TV) by Wyeth Laboratories (Trade Name: RotaShield).
CC   Senescence: Senesces at ~74 PDL.
CC   Discontinued: ATCC; CCL-160; true.
CC   Discontinued: IZSLER; BS CL 215; probable.
CC   Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=9544; ! Macaca mulatta (Rhesus macaque)
SX   Male
AG   Fetus
CA   Finite cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 18
//
RX   Patent=US4040905;
RA   Petricciani J.C., Hopps H.E., Lorenz D.E., Vasington P.J.,
RA   Wallace R.E.;
RT   "Sub-human primate diploid cell lines as substrates for virus vaccine
RT   production.";
RL   Patent number US4040905, 09-Aug-1977.
//
RX   PubMed=4203458;
RA   Petricciani J.C., Wallace R.E., McCoy D.W.;
RT   "A comparison of three in vivo assays for cell tumorigenicity.";
RL   Cancer Res. 34:105-108(1974).
//
RX   PubMed=4348695; DOI=10.1007/BF02619056;
RA   Wallace R.E., Vasington P.J., Petricciani J.C., Hopps H.E.,
RA   Lorenz D.E., Kadanka Z.;
RT   "Development of a diploid cell line from fetal rhesus monkey lung for
RT   virus vaccine production.";
RL   In Vitro 8:323-332(1973).
//
RX   PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222;
RA   Hay R.J., Williams C.D., Macy M.L., Lavappa K.S.;
RT   "Cultured cell lines for research on pulmonary physiology available
RT   through the American Type Culture Collection.";
RL   Am. Rev. Respir. Dis. 125:222-232(1982).
//