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Cellosaurus CTAC (CVCL_4155)

[Text version]
Cell line name CTAC
Synonyms C_TAC
Accession CVCL_4155
Resource Identification Initiative To cite this cell line use: CTAC (RRID:CVCL_4155)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 15 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; VGNC; 40436; ERBB2; Simple; p.Val659Glu (c.1976T>A); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Thr114Met (c.341C>T); Zygosity=Homozygous (PubMed=31175136).
Disease Canine thyroid adenocarcinoma (NCIt: C132275)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Boxer.
Sex of cell Female
Age at sampling 7Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010227,231
Dog FHC2054151,164
Dog FHC2079275
Dog PEZ1119
Dog PEZ12263,277
Dog PEZ20176
Dog PEZ3113,119
Dog PEZ5103,115
Dog PEZ6179,183
Dog PEZ8228,240

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Publications

PubMed=14266865
Kasza L.
Establishment and characterization of canine thyroid adenocarcinoma and canine melanoma cell lines.
Am. J. Vet. Res. 25:1178-1185(1964)

PubMed=29991117; DOI=10.1177/030098586700400405
Kasza L., Griesemer R.A.
The production of cytopathic changes in canine cell lines by infectious agents: cell lines derived from melanoma and thyroidal carcinoma.
Pathol. Vet. 4:378-390(1967)

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=26842912; DOI=10.1111/vco.12197
Hartley G., Faulhaber E., Caldwell A., Coy J., Kurihara J., Guth A., Regan D.P., Dow S.W.
Immune regulation of canine tumour and macrophage PD-L1 expression.
Vet. Comp. Oncol. 15:534-549(2017)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Cell line collections (Providers) ECACC; 90071812
Encyclopedic resources Wikidata; Q54814728
Gene expression databases GEO; GSM1974777
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17