ID   CTAC
AC   CVCL_4155
SY   C_TAC
DR   ECACC; 90071812
DR   GEO; GSM1974777
DR   Wikidata; Q54814728
RX   PubMed=14266865;
RX   PubMed=21908323;
RX   PubMed=26842912;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=29991117;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 15 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; 40436; ERBB2; Simple; p.Val659Glu (c.1976T>A); Zygosity=Homozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; 47719; TP53; Simple; p.Thr114Met (c.341C>T); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
CC   Breed/subspecies: Boxer.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 227,231
ST   Dog FHC2054: 151,164
ST   Dog FHC2079: 275
ST   Dog PEZ1: 119
ST   Dog PEZ3: 113,119
ST   Dog PEZ5: 103,115
ST   Dog PEZ6: 179,183
ST   Dog PEZ8: 228,240
ST   Dog PEZ12: 263,277
ST   Dog PEZ20: 176
DI   NCIt; C132275; Canine thyroid adenocarcinoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Female
AG   7Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 17
//
RX   PubMed=14266865;
RA   Kasza L.;
RT   "Establishment and characterization of canine thyroid adenocarcinoma
RT   and canine melanoma cell lines.";
RL   Am. J. Vet. Res. 25:1178-1185(1964).
//
RX   PubMed=21908323; DOI=10.1177/1040638711408064;
RA   O'Donoghue L.E., Rivest J.P., Duval D.L.;
RT   "Polymerase chain reaction-based species verification and
RT   microsatellite analysis for canine cell line validation.";
RL   J. Vet. Diagn. Invest. 23:780-785(2011).
//
RX   PubMed=26842912; DOI=10.1111/vco.12197;
RA   Hartley G., Faulhaber E.A., Caldwell A., Coy J., Kurihara J.N.,
RA   Guth A., Regan D.P., Dow S.W.;
RT   "Immune regulation of canine tumour and macrophage PD-L1 expression.";
RL   Vet. Comp. Oncol. 15:534-549(2017).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
//
RX   PubMed=29991117; DOI=10.1177/030098586700400405;
RA   Kasza L., Griesemer R.A.;
RT   "The production of cytopathic changes in canine cell lines by
RT   infectious agents: cell lines derived from melanoma and thyroidal
RT   carcinoma.";
RL   Pathol. Vet. 4:378-390(1967).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//