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Cellosaurus KKU-100 (CVCL_3996)

[Text version]
Cell line name KKU-100
Synonyms KKU100; K100
Accession CVCL_3996
Resource Identification Initiative To cite this cell line use: KKU-100 (RRID:CVCL_3996)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Southeast Asian; Thai.
Doubling time: ~72 hours (PubMed=15948244).
Omics: Deep exome analysis.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=29110582; DepMap=ACH-001536).
Disease Hilar cholangiocarcinoma (NCIt: C36077)
Opisthorchis viverrini-related cholangiocarcinoma (NCIt: C27769)
Klatskin tumor (ORDO: Orphanet_99978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001536; JCRB=JCRB1568

Markers:
AmelogeninX
CSF1PO11,13
D3S135816,17
D5S81811,13
D7S8208,11
D8S117910,15
D13S3179
D16S53910,11
D18S5113
D21S1131.2,33.2
FGA22,25
Penta D11
Penta E9,11
TH018,9
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=12587840
Panichakul T., Wanun T., Reutrakul V., Sirisinha S.
Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-alpha) and triptolide.
Asian Pac. J. Allergy Immunol. 20:167-173(2002)

PubMed=15884115; DOI=10.3748/wjg.v11.i18.2748; PMCID=PMC4305909
Tepsiri N., Chaturat L., Sripa B., Namwat W., Wongkham S., Bhudhisawasdi V., Tassaneeyakul W.
Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines.
World J. Gastroenterol. 11:2748-2753(2005)

PubMed=15948244; DOI=10.3748/wjg.v11.i22.3392; PMCID=PMC4315993
Sripa B., Leungwattanawanit S., Nitta T., Wongkham C., Bhudhisawasdi V., Puapairoj A., Sripa C., Miwa M.
Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100).
World J. Gastroenterol. 11:3392-3397(2005)

PubMed=16475706
Panichakul T., Intachote P., Wongkajornsilp A., Sripa B., Sirisinha S.
Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.
Anticancer Res. 26:259-265(2006)

PubMed=20493868; DOI=10.1016/j.ijpara.2010.05.002; PMCID=PMC3739719
Yonglitthipagon P., Pairojkul C., Chamgramol Y., Mulvenna J., Sripa B.
Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker.
Int. J. Parasitol. 40:1203-1212(2010)

PubMed=21871105; DOI=10.1186/1476-4598-10-102; PMCID=PMC3173387
Obchoei S., Weakley S.M., Wongkham S., Wongkham C., Sawanyawisuth K., Yao Q.-Z., Chen C.-Y.
Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma.
Mol. Cancer 10:102.1-102.15(2011)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=29110582; DOI=10.1177/1010428317725925
Saensa-ard S., Leuangwattanawanit S., Senggunprai L., Namwat N., Kongpetch S., Chamgramol Y., Loilome W., Khansaard W., Jusakul A., Prawan A., Pairojkul C., Khantikeo N., Yongvanit P., Kukongviriyapan V.
Establishment of cholangiocarcinoma cell lines from patients in the endemic area of liver fluke infection in Thailand.
Tumor Biol. 39:1010428317725925-1010428317725925(2017)

PubMed=31077409; DOI=10.1002/hep.30704
Sittithumcharee G., Suppramote O., Vaeteewoottacharn K., Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M., Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K., Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P., Pairojkul C., Wongkham S., Sampattavanich S., Okada S., Jirawatnotai S.
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1568
Cell line databases/resources cancercelllines; CVCL_3996
Cell_Model_Passport; SIDM01579
DepMap; ACH-001536
Anatomy/cell type resources BTO; BTO:0003934
Encyclopedic resources Wikidata; Q54900002
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23