Cellosaurus logo
expasy logo

Cellosaurus KKU-100 (CVCL_3996)

[Text version]
Cell line name KKU-100
Synonyms KKU100; K100; Khon Kaen University-100
Accession CVCL_3996
Resource Identification Initiative To cite this cell line use: KKU-100 (RRID:CVCL_3996)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Southeast Asian; Thai.
Doubling time: ~72 hours (PubMed=15948244).
Omics: Genomics; Whole exome sequencing.
Sequence variations
Disease Hilar cholangiocarcinoma (NCIt: C36077)
Opisthorchis viverrini-related cholangiocarcinoma (NCIt: C27769)
Klatskin tumor (ORDO: Orphanet_99978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001536; JCRB=JCRB1568

Markers:
AmelogeninX
CSF1PO11,13
D3S135816,17
D5S81811,13
D7S8208,11
D8S117910,15
D13S3179
D16S53910,11
D18S5113
D21S1131.2,33.2
FGA22,25
Penta D11
Penta E9,11
TH018,9
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=12587840
Tasanee Panichakul, Thiwaree Wanun, Vichai Reutrakul, Stitaya Sirisinha;
Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-alpha) and triptolide.
Asian Pac. J. Allergy Immunol. 20:167-173(2002)

PubMed=15884115; DOI=10.3748/wjg.v11.i18.2748; PMCID=PMC4305909
Nisana Tepsiri, Liengchai Chaturat, Banchob Sripa, Wises Namwat, Sopit Wongkham, Vajarabhongsa Bhudhisawasdi, Wichittra Tassaneeyakul;
Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines.
World J. Gastroenterol. 11:2748-2753(2005)

PubMed=15948244; DOI=10.3748/wjg.v11.i22.3392; PMCID=PMC4315993
Banchob Sripa, Saman Leungwattanawanit, Takayuki Nitta, Chaisiri Wongkham, Vajarabhongsa Bhudhisawasdi, Anucha Puapairoj, Chongrak Sripa, Masanao Miwa;
Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100).
World J. Gastroenterol. 11:3392-3397(2005)

PubMed=16475706
Tasanee Panichakul, Pakamas Intachote, Adisak Wongkajornsilp, Banchob Sripa, Stitaya Sirisinha;
Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.
Anticancer Res. 26:259-265(2006)

PubMed=20493868; DOI=10.1016/j.ijpara.2010.05.002; PMCID=PMC3739719
Ponlapat Yonglitthipagon, Chawalit Pairojkul, Yaovalux Chamgramol, Jason Mulvenna, Banchob Sripa;
Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker.
Int. J. Parasitol. 40:1203-1212(2010)

PubMed=21871105; DOI=10.1186/1476-4598-10-102; PMCID=PMC3173387
Sumalee Obchoei, Sarah M. Weakley, Sopit Wongkham, Chaisiri Wongkham, Kanlayanee Sawanyawisuth, Qi-Zhi Yao, Chang-Yi Chen;
Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma.
Mol. Cancer 10:102.1-102.15(2011)

CLPUB00275
Sebastian Zach, Emrullah Birgin, Felix Ruckert;
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=29110582; DOI=10.1177/1010428317725925
Sunitta Saensa-ard, Saman Leuangwattanawanit, Laddawan Senggunprai, Nisana Namwat, Sarinya Kongpetch, Yaovalux Chamgramol, Watcharin Loilome, Walaiporn Khansaard, Apinya Jusakul, Auemduan Prawan, Chawalit Pairojkul ...Show all 14 authors... , Narong Khantikeo, Puangrat Yongvanit, Veerapol Kukongviriyapan; Show fewer authors
Establishment of cholangiocarcinoma cell lines from patients in the endemic area of liver fluke infection in Thailand.
Tumor Biol. 39:1010428317725925-1010428317725925(2017)

PubMed=31077409; DOI=10.1002/hep.30704
Gunya Sittithumcharee, Orawan Suppramote, Kulthida Vaeteewoottacharn, Chumphon Sirisuksakun, Supawan Jamnongsong, Phatthamon Laphanuwat, Monthira Suntiparpluacha, Arriya Matha, Porncheera Chusorn, Pongsakorn Buraphat, Chumpot Kakanaporn ...Show all 21 authors... , Komgrid Charngkaew, Atit Silsirivanit, Krittiya Korphaisarn, Somchai Limsrichamrern, Pinpat Tripatara, Chawalit Pairojkul, Sopit Wongkham, Somponnat Sampattavanich, Seiji Okada, Siwanon Jirawatnotai; Show fewer authors
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line collections (Providers) JCRB; JCRB1568
Cell line databases/resources cancercelllines; CVCL_3996
Cell_Model_Passport; SIDM01579
DepMap; ACH-001536
Anatomy/cell type resources BTO; BTO_0003934
Encyclopedic resources Wikidata; Q54900002
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25