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Cellosaurus CWR22 (CVCL_3967)

[Text version]
Cell line name CWR22
Synonyms CWR-22; CWR 22
Accession CVCL_3967
Resource Identification Initiative To cite this cell line use: CWR22 (RRID:CVCL_3967)
Comments Population: Caucasian.
Microsatellite instability: Instable (MSI) (PubMed=23671654).
Miscellaneous: This is not a cell line but a xenograft, it is the parent tumor for many cell lines.
Misspelling: CRW22; Note=Occasionally.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (from child cell line CWR22Pc).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1045 (22Rv1)CVCL_4833 (CWR-R1)CVCL_LI38 (CWR22Pc)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=8433392; DOI=10.1093/jnci/85.5.394
Thomas G. Pretlow 2nd, Sandra R. Wolman, Mark A. Micale, Robert J. Pelley, Elroy D. Kursh, Martin I. Resnick, Donald Roger Bodner, James W. Jacobberger, Carrie Marie Delmoro, Joseph M. Giaconia, Theresa P. Pretlow;
Xenografts of primary human prostatic carcinoma.
J. Natl. Cancer Inst. 85:394-398(1993)

PubMed=7525052
Mark Alan Wainstein, Feng He, Daniel Robinson, Hsing-Jien Kung, Stuart Schwartz, Joseph M. Giaconia, Nancy L. Edgehouse, Theresa P. Pretlow, Donald Roger Bodner, Elroy D. Kursh, Martin I. Resnick ...Show all 13 authors... , Allen Seftel, Thomas G. Pretlow 2nd; Show fewer authors
CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma.
Cancer Res. 54:6049-6052(1994)

PubMed=8674060
Moolky Nagabhushan, Casey M. Miller, Theresa P. Pretlow, Joseph M. Giaconia, Nancy L. Edgehouse, Stuart Schwartz, Hsing-Jien Kung, Ralph W. deVere White, Paul Howard Gumerlock, Martin I. Resnick, Saeid B. Amini, Thomas G. Pretlow 2nd;
CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar.
Cancer Res. 56:3042-3046(1996)

PubMed=10861745; DOI=10.1002/1097-0045(20000601)43:4<263::AID-PROS5>3.0.CO;2-I
Wytske M. van Weerden, Johannes C. Romijn;
Use of nude mouse xenograft models in prostate cancer research.
Prostate 43:263-271(2000)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

Cross-references
Cell line collections (Providers) NCI-DTP; CWR-22
Cell line databases/resources cancercelllines; CVCL_3967
Anatomy/cell type resources BTO; BTO_0004594
Encyclopedic resources Wikidata; Q54817054
Experimental variables resources EFO; EFO_0022459
Polymorphism and mutation databases Cosmic; 1689706
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number22