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Cellosaurus CWR22 (CVCL_3967)

[Text version]

Cell line name CWR22
Synonyms CWR-22; CWR 22
Accession CVCL_3967
Resource Identification Initiative To cite this cell line use: CWR22 (RRID:CVCL_3967)
Comments Microsatellite instability: Instable (MSI) (PubMed=23671654).
Miscellaneous: This is not a cell line but a xenograft, it is the parent tumor for many cell lines.
Misspelling: CRW22; Occasionally.
Derived from sampling site: Prostate.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous.
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1045 (22Rv1 )CVCL_4833 (CWR-R1 )CVCL_LI38 (CWR22Pc )
Sex of cell Male
Age at sampling Adult
Category Cancer cell line

PubMed=8433392; DOI=10.1093/jnci/85.5.394
Pretlow T.G. II, Wolman S.R., Micale M.A., Pelley R.J., Kursh E.D., Resnick M.I., Bodner D.R., Jacobberger J.W., Delmoro C.M., Giaconia J.M., Pretlow T.P.
Xenografts of primary human prostatic carcinoma.
J. Natl. Cancer Inst. 85:394-398(1993)

Wainstein M.A., He F., Robinson D., Kung H.-J., Schwartz S., Giaconia J.M., Edgehouse N.L., Pretlow T.P., Bodner D.R., Kursh E.D., Resnick M.I., Seftel A., Pretlow T.G. II
CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma.
Cancer Res. 54:6049-6052(1994)

Nagabhushan M., Miller C.M., Pretlow T.P., Giaconia J.M., Edgehouse N.L., Schwartz S., Kung H.-J., de Vere White R.W., Gumerlock P.H., Resnick M.I., Amini S.B., Pretlow T.G. II
CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar.
Cancer Res. 56:3042-3046(1996)

PubMed=10861745; DOI=10.1002/1097-0045(20000601)43:4<263::AID-PROS5>3.0.CO;2-I
van Weerden W.M., Romijn J.C.
Use of nude mouse xenograft models in prostate cancer research.
Prostate 43:263-271(2000)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y.-H., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

Cell line collections NCI-DTP; CWR-22
Anatomy/cell type resources BTO; BTO:0004594
Encyclopedic resources Wikidata; Q54817054
Polymorphism and mutation databases Cosmic; 1689706
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number16