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Cellosaurus SNU-354 (CVCL_3947)

[Text version]
Cell line name SNU-354
Synonyms SNU354
Accession CVCL_3947
Resource Identification Initiative To cite this cell line use: SNU-354 (RRID:CVCL_3947)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 34 hours (PubMed=7543080); 39.48 hours (PubMed=31378681).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:18037; ARID2; Simple; p.Ala1090Cysfs*5 (c.3267dupT); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:18037; ARID2; Simple; p.Gly1424Valfs*5 (c.4271delG); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Lys515Ter (c.1543A>T); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): KCLB=00354; PubMed=31378681

Markers:
AmelogeninX,Y
CSF1PO8,11
D3S135815,17
D5S81811,12
D7S8207,11
D13S31710,11
D16S53910
FGA21,22
TH019
TPOX11
vWA17

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/SNU354
Publications

PubMed=7543080; DOI=10.1002/ijc.2910620308
Jae-Gahb Park, Jae-Ho Lee, Myung-Soo Kang, Kyu-Joo Park, You-Me Jeon, Hyun-Ju Lee, Hae-Sung Kwon, Hyun-Sook Park, Kyong-Sook Yeo, Kuhn-Uk Lee, Soo-Tae Kim ...Show all 22 authors... , June-Key Chung, You-Jin Hwang, Hyo-Suk Lee, Chung Yong Kim, Young Ik Lee, Tchaw-Ren Chen, Robert J. Hay, Sang-Yong Song, Woo-Ho Kim, Chul-Woo Ki, Young-Il Kim; Show fewer authors
Characterization of cell lines established from human hepatocellular carcinoma.
Int. J. Cancer 62:276-282(1995)

PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X
Myung-Soo Kang, Hong-Joo Lee, Jae-Ho Lee, Ja-Lok Ku, Kathreen P. Lee, Michael J. Kelley, Yong-Jin Won, Soo-Tae Kim, Jae-Gahb Park;
Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX DNA.
Int. J. Cancer 67:898-902(1996)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416
Ja-Lok Ku, Jae-Gahb Park;
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=16616112; DOI=10.1016/j.cancergencyto.2005.08.022
Sang-Jin Park, Seon-Yong Jeong, Hyon-Ju Kim;
Y chromosome loss and other genomic alterations in hepatocellular carcinoma cell lines analyzed by CGH and CGH array.
Cancer Genet. Cytogenet. 166:56-64(2006)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Stefano Caruso, Anna-Line Calatayud, Jill Pilet, Tiziana La Bella, Samia Rekik, Sandrine Imbeaud, Eric Letouze, Lea Meunier, Quentin Bayard, Nataliya Rohr-Udilova, Camille Peneau ...Show all 20 authors... , Bettina Grasl-Kraupp, Leanne de Koning, Berengere Ouine, Paulette Bioulac-Sage, Gabrielle Couchy, Julien Calderaro, Jean-Charles Nault, Jessica Zucman-Rossi, Sandra Rebouissou; Show fewer authors
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line collections (Providers) KCLB; 00354
Cell line databases/resources LIMORE; SNU354
Anatomy/cell type resources BTO; BTO_0003190
Chemistry resources ChEMBL-Cells; CHEMBL3307310
ChEMBL-Targets; CHEMBL614165
PubChem_Cell_line; CVCL_3947
Encyclopedic resources Wikidata; Q54955178
Gene expression databases GEO; GSM1374888
GEO; GSM2551584
Polymorphism and mutation databases Cosmic; 2023865
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26