ID   SNU-354
AC   CVCL_3947
SY   SNU354
DR   BTO; BTO_0003190
DR   ChEMBL-Cells; CHEMBL3307310
DR   ChEMBL-Targets; CHEMBL614165
DR   Cosmic; 2023865
DR   GEO; GSM1374888
DR   GEO; GSM2551584
DR   KCLB; 00354
DR   LIMORE; SNU354
DR   PubChem_Cell_line; CVCL_3947
DR   Wikidata; Q54955178
RX   PubMed=7543080;
RX   PubMed=8824565;
RX   PubMed=16616112;
RX   PubMed=19956504;
RX   PubMed=31063779;
RX   PubMed=31378681;
WW   Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/SNU354
CC   Part of: Liver Cancer Model Repository (LIMORE).
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Population: Korean.
CC   Doubling time: 34 hours (PubMed=7543080); 39.48 hours (PubMed=31378681).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; HGNC:18037; ARID2; Simple; p.Ala1090Cysfs*5 (c.3267dupT); Zygosity=Unspecified (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:18037; ARID2; Simple; p.Gly1424Valfs*5 (c.4271delG); Zygosity=Unspecified (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Lys515Ter (c.1543A>T); Zygosity=Unspecified (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): KCLB=00354; PubMed=31378681
ST   Amelogenin: X,Y
ST   CSF1PO: 8,11
ST   D13S317: 10,11
ST   D16S539: 10
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 7,11
ST   FGA: 21,22
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724;
RA   Qiu, Zhi-Xin
RA   Li, Hong
RA   Zhang, Zheng-Tao
RA   Zhu, Zhen-Feng
RA   He, Sheng
RA   Wang, Xu-Jun
RA   Wang, Peng-Cheng
RA   Qin, Jian-Jie
RA   Zhuang, Li-Ping
RA   Wang, Wei
RA   Xie, Fu-Bo
RA   Gu, Ying
RA   Zou, Ke-Ke
RA   Li, Chao
RA   Li, Chun
RA   Wang, Chen-Hua
RA   Cen, Jin
RA   Chen, Xiao-Tao
RA   Shu, Ya-Jing
RA   Zhang, Zhao
RA   Sun, Lu-Lu
RA   Min, Li-Hua
RA   Fu, Yong
RA   Huang, Xiao-Wu
RA   Lv, Hui
RA   Zhou, He
RA   Ji, Yuan
RA   Zhang, Zhi-Gang
RA   Meng, Zhi-Qiang
RA   Shi, Xiao-Lei
RA   Zhang, Hai-Bin
RA   Li, Yi-Xue
RA   Hui, Li-Jian
RT   "A pharmacogenomic landscape in human liver cancers.";
RL   Cancer Cell 36:179-193.e11(2019).
//
RX   PubMed=16616112; DOI=10.1016/j.cancergencyto.2005.08.022;
RA   Park, Sang-Jin
RA   Jeong, Seon-Yong
RA   Kim, Hyon-Ju
RT   "Y chromosome loss and other genomic alterations in hepatocellular
RT   carcinoma cell lines analyzed by CGH and CGH array.";
RL   Cancer Genet. Cytogenet. 166:56-64(2006).
//
RX   PubMed=7543080; DOI=10.1002/ijc.2910620308;
RA   Park, Jae-Gahb
RA   Lee, Jae-Ho
RA   Kang, Myung-Soo
RA   Park, Kyu-Joo
RA   Jeon, You-Me
RA   Lee, Hyun-Ju
RA   Kwon, Hae-Sung
RA   Park, Hyun-Sook
RA   Yeo, Kyong-Sook
RA   Lee, Kuhn-Uk
RA   Kim, Soo-Tae
RA   Chung, June-Key
RA   Hwang, You-Jin
RA   Lee, Hyo-Suk
RA   Kim, Chung Yong
RA   Lee, Young Ik
RA   Chen, Tchaw-Ren
RA   Hay, Robert J.
RA   Song, Sang-Yong
RA   Kim, Woo-Ho
RA   Ki, Chul-Woo
RA   Kim, Young-Il
RT   "Characterization of cell lines established from human hepatocellular
RT   carcinoma.";
RL   Int. J. Cancer 62:276-282(1995).
//
RX   PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X;
RA   Kang, Myung-Soo
RA   Lee, Hong-Joo
RA   Lee, Jae-Ho
RA   Ku, Ja-Lok
RA   Lee, Kathreen P.
RA   Kelley, Michael J.
RA   Won, Yong-Jin
RA   Kim, Soo-Tae
RA   Park, Jae-Gahb
RT   "Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX
RT   DNA.";
RL   Int. J. Cancer 67:898-902(1996).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416;
RA   Ku, Ja-Lok
RA   Park, Jae-Gahb
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001;
RA   Caruso, Stefano
RA   Calatayud, Anna-Line
RA   Pilet, Jill
RA   La Bella, Tiziana
RA   Rekik, Samia
RA   Imbeaud, Sandrine
RA   Letouze, Eric
RA   Meunier, Lea
RA   Bayard, Quentin
RA   Rohr-Udilova, Nataliya
RA   Peneau, Camille
RA   Grasl-Kraupp, Bettina
RA   de Koning, Leanne
RA   Ouine, Berengere
RA   Bioulac-Sage, Paulette
RA   Couchy, Gabrielle
RA   Calderaro, Julien
RA   Nault, Jean-Charles
RA   Zucman-Rossi, Jessica
RA   Rebouissou, Sandra
RT   "Analysis of liver cancer cell lines identifies agents with likely
RT   efficacy against hepatocellular carcinoma and markers of response.";
RL   Gastroenterology 157:760-776(2019).
//