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Cellosaurus OVCA420 (CVCL_3935)

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Cell line name OVCA420
Synonyms OVCA 420; OvCa 420; OVCA-420; OVCAR-420; OVCAR 420; OVCAR420
Accession CVCL_3935
Resource Identification Initiative To cite this cell line use: OVCA420 (RRID:CVCL_3935)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: African American.
Doubling time: 47.62 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*30:01,30:01
HLA-BB*42:01,48:17
HLA-CC*04:01,17:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African82.47
Native American0
East Asian, North2.6
East Asian, South0
South Asian2.8
European, North3.32
European, South8.81
Disease Ovarian serous adenocarcinoma (NCIt: C7550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1480364; PubMed=22115851; PubMed=22710073; PubMed=25877200

Markers:
AmelogeninX
CSF1PO8
D2S133819,22
D3S135816,17
D5S81813
D7S8208,11 (PubMed=25877200)
11 (Cosmic-CLP=1480364; PubMed=22115851; PubMed=22710073)
D8S117914,15
D13S31712,13
D16S5399 (PubMed=22115851; PubMed=22710073)
9,12 (Cosmic-CLP=1480364; PubMed=25877200)
D18S5114,17
D19S43311,15.2
D21S1130.2
FGA21,22 (PubMed=25877200)
22 (PubMed=22115851; PubMed=22710073)
Penta D12
Penta E5,8
TH016 (PubMed=22710073; PubMed=25877200)
6,9 (Cosmic-CLP=1480364)
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=7028788; DOI=10.1172/JCI110380; PMCID=PMC370929
Robert Clinton Bast Jr., Maryellen Feeney, Herbert Lazarus, Lee Marshall Nadler, Robert B. Colvin, Robert C. Knapp;
Reactivity of a monoclonal antibody with human ovarian carcinoma.
J. Clin. Invest. 68:1331-1337(1981)

PubMed=6346879; DOI=10.1016/0002-9378(83)90999-7
Ross Stuart Berkowitz, Salim Kabawat, Herbert Lazarus, Robert B. Colvin, Robert C. Knapp, Robert Clinton Bast Jr.;
Comparison of a rabbit heteroantiserum and a murine monoclonal antibody raised against a human epithelial ovarian carcinoma cell line.
Am. J. Obstet. Gynecol. 146:607-612(1983)

PubMed=1536252; DOI=10.1016/0002-9378(92)91697-9
Andrew Berchuck, Gus Rodriguez, George Olt, Regina Whitaker, Matthew P. Boente, Bradley A. Arrick, Daniel Lyle Clarke-Pearson, Robert Clinton Bast Jr.;
Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta.
Am. J. Obstet. Gynecol. 166:676-684(1992)

PubMed=10318951; DOI=10.1073/pnas.96.10.5722; PMCID=PMC21927
Kin-Mang Lau, Samuel C. Mok, Shuk-Mei Ho;
Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 96:5722-5727(1999)

PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H
Christine Rauh-Adelmann, Kin-Mang Lau, Nari Sabeti, John P. Long, Samuel C. Mok, Shuk-Mei Ho;
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Mol. Carcinog. 28:236-246(2000)

PubMed=11793438; DOI=10.1002/gcc.1221
Pulivarthi H. Rao, Charles P. Harris, Xin-Yan Lu, Xiao-Nan Li, Samuel C. Mok, Ching C. Lau;
Multicolor spectral karyotyping of serous ovarian adenocarcinoma.
Genes Chromosomes Cancer 33:123-132(2002)

PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758
Marci E. Schaner, Douglas T. Ross, Giuseppe Ciaravino, Therese Sorlie, Olga G. Troyanskaya, Maximilian Diehn, Yan C. Wang, George E. Duran, Thomas L. Sikic, Sandra Caldeira, Hanne Skomedal ...Show all 26 authors... , I-Ping Tu, Tina Hernandez-Boussard, Steven W. Johnson, Peter J. O'Dwyer, Michael J. Fero, Gunnar B. Kristensen, Anne-Lise Borresen-Dale, Trevor John Hastie, Robert Tibshirani, Matt van de Rijn, Nelson N.H. Teng, Teri A. Longacre, David Botstein, Patrick O'Reilly Brown, Branimir I. Sikic; Show fewer authors
Gene expression patterns in ovarian carcinomas.
Mol. Biol. Cell 14:4376-4386(2003)

PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445
Gregory T. Langland, Steven M. Yannone, Rachel A. Langland, Aki Nakao, Ying-Hui Guan, Sydney B.T. Long, Lien Vonguyen, David J. Chen, Joe W. Gray, Fan-Qing Chen;
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Oncol. Rep. 23:1021-1026(2010)

PubMed=22115851; DOI=10.1016/j.ygyno.2011.11.019; PMCID=PMC3468155
Prakash Vishnu, Gerardo Colon-Otero, Gregory T. Kennedy, Laura A. Marlow, William P. Kennedy, Kevin J. Wu, Joseph T. Santoso, John Alton Copland 3rd;
RhoB mediates antitumor synergy of combined ixabepilone and sunitinib in human ovarian serous cancer.
Gynecol. Oncol. 124:589-597(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul M. Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Jose Suarez Saiz ...Show all 19 authors... , Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny I. Drapkin, Laurie Ailles, Anne-Marie Mes-Masson, Robert Rottapel; Show fewer authors
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3935
Cell_Model_Passport; SIDM00967
Cosmic-CLP; 1480364
DepMap; ACH-002181
Anatomy/cell type resources BTO; BTO_0002563
Biological sample resources BioSample; SAMN03471874
CRISP screens repositories BioGRID_ORCS_Cell_line; 980
Chemistry resources GDSC; 1480364
PharmacoDB; OVCA420_1213_2019
Encyclopedic resources Wikidata; Q54936981
Experimental variables resources EFO; EFO_0006720
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM659390
GEO; GSM711703
GEO; GSM851928
GEO; GSM1340585
GEO; GSM1341130
GEO; GSM1670315
GEO; GSM2474990
Polymorphism and mutation databases Cosmic; 924145
Cosmic; 927566
IARC_TP53; 28490
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37