ID   OVCA420
AC   CVCL_3935
SY   OVCA 420; OvCa 420; OVCA-420; OVCAR-420; OVCAR 420; OVCAR420
DR   BTO; BTO_0002563
DR   EFO; EFO_0006720
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 980
DR   BioSample; SAMN03471874
DR   cancercelllines; CVCL_3935
DR   Cell_Model_Passport; SIDM00967
DR   Cosmic; 924145
DR   Cosmic; 927566
DR   Cosmic-CLP; 1480364
DR   DepMap; ACH-002181
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 1480364
DR   GEO; GSM659390
DR   GEO; GSM711703
DR   GEO; GSM851928
DR   GEO; GSM1340585
DR   GEO; GSM1341130
DR   GEO; GSM1670315
DR   GEO; GSM2474990
DR   IARC_TP53; 28490
DR   PharmacoDB; OVCA420_1213_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54936981
RX   PubMed=1536252;
RX   PubMed=6346879;
RX   PubMed=7028788;
RX   PubMed=10318951;
RX   PubMed=10972993;
RX   PubMed=11793438;
RX   PubMed=12960427;
RX   PubMed=20204287;
RX   PubMed=22115851;
RX   PubMed=22710073;
RX   PubMed=23415752;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=28273451;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: African American.
CC   Doubling time: 47.62 hours (JWGray panel).
CC   HLA typing: A*30:01,30:01; B*42:01,48:17; C*04:01,17:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=20204287; PubMed=28273451).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=82.47%; Native American=0%; East Asian, North=2.6%; East Asian, South=0%; South Asian=2.8%; European, North=3.32%; European, South=8.81% (PubMed=30894373).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
ST   Source(s): Cosmic-CLP=1480364; PubMed=22115851; PubMed=22710073; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 8
ST   D13S317: 12,13
ST   D16S539: 9 (PubMed=22115851; PubMed=22710073)
ST   D16S539: 9,12 (Cosmic-CLP=1480364; PubMed=25877200)
ST   D18S51: 14,17
ST   D19S433: 11,15.2
ST   D21S11: 30.2
ST   D2S1338: 19,22
ST   D3S1358: 16,17
ST   D5S818: 13
ST   D7S820: 8,11 (PubMed=25877200)
ST   D7S820: 11 (Cosmic-CLP=1480364; PubMed=22115851; PubMed=22710073)
ST   D8S1179: 14,15
ST   FGA: 21,22 (PubMed=25877200)
ST   FGA: 22 (PubMed=22115851; PubMed=22710073)
ST   Penta D: 12
ST   Penta E: 5,8
ST   TH01: 6 (PubMed=22710073; PubMed=25877200)
ST   TH01: 6,9 (Cosmic-CLP=1480364)
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C7550; Ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 37
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758;
RA   Schaner, Marci E.
RA   Ross, Douglas T.
RA   Ciaravino, Giuseppe
RA   Sorlie, Therese
RA   Troyanskaya, Olga G.
RA   Diehn, Maximilian
RA   Wang, Yan C.
RA   Duran, George E.
RA   Sikic, Thomas L.
RA   Caldeira, Sandra
RA   Skomedal, Hanne
RA   Tu, I-Ping
RA   Hernandez-Boussard, Tina
RA   Johnson, Steven W.
RA   O'Dwyer, Peter J.
RA   Fero, Michael J.
RA   Kristensen, Gunnar B.
RA   Borresen-Dale, Anne-Lise
RA   Hastie, Trevor John
RA   Tibshirani, Robert John
RA   van de Rijn, Matt
RA   Teng, Nelson N.H.
RA   Longacre, Teri A.
RA   Botstein, David
RA   Brown, Patrick O'Reilly
RA   Sikic, Branimir Ivan
RT   "Gene expression patterns in ovarian carcinomas.";
RL   Mol. Biol. Cell 14:4376-4386(2003).
//
RX   PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028;
RA   Medrano, Mauricio
RA   Communal, Laudine
RA   Brown, Kevin R.
RA   Iwanicki, Marcin
RA   Normand, Josee
RA   Paterson, Joshua
RA   Sircoulomb, Fabrice
RA   Krzyzanowski, Paul M.
RA   Novak, Marian
RA   Doodnauth, Sasha A.
RA   Suarez Saiz, Fernando Jose
RA   Cullis, Jane
RA   Al-awar, Rima
RA   Neel, Benjamin G.
RA   McPherson, John
RA   Drapkin, Ronny I.
RA   Ailles, Laurie
RA   Mes-Masson, Anne-Marie
RA   Rottapel, Robert
RT   "Interrogation of functional cell-surface markers identifies CD151
RT   dependency in high-grade serous ovarian cancer.";
RL   Cell Rep. 18:2343-2358(2017).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445;
RA   Langland, Gregory T.
RA   Yannone, Steven M.
RA   Langland, Rachel A.
RA   Nakao, Aki
RA   Guan, Ying-Hui
RA   Long, Sydney B.T.
RA   Vonguyen, Lien
RA   Chen, David J.
RA   Gray, Joe W.
RA   Chen, Fan-Qing
RT   "Radiosensitivity profiles from a panel of ovarian cancer cell lines
RT   exhibiting genetic alterations in p53 and disparate DNA-dependent
RT   protein kinase activities.";
RL   Oncol. Rep. 23:1021-1026(2010).
//
RX   PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023;
RA   Stordal, Britta
RA   Timms, Kirsten
RA   Farrelly, Angela
RA   Gallagher, Danielle
RA   Busschots, Steven
RA   Renaud, Mickael
RA   Thery, Julien
RA   Williams, Deborah
RA   Potter, Jennifer
RA   Tran, Thanh
RA   Korpanty, Greg
RA   Cremona, Mattia
RA   Carey, Mark S.
RA   Li, Jie
RA   Li, Yang
RA   Aslan, Ozlem
RA   O'Leary, John J.
RA   Mills, Gordon B.
RA   Hennessy, Bryan T.
RT   "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one
RT   functionally deleterious BRCA1 mutation.";
RL   Mol. Oncol. 7:567-579(2013).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=6346879; DOI=10.1016/0002-9378(83)90999-7;
RA   Berkowitz, Ross Stuart
RA   Kabawat, Salim
RA   Lazarus, Herbert
RA   Colvin, Robert B.
RA   Knapp, Robert C.
RA   Bast, Robert Clinton Jr.
RT   "Comparison of a rabbit heteroantiserum and a murine monoclonal
RT   antibody raised against a human epithelial ovarian carcinoma cell
RT   line.";
RL   Am. J. Obstet. Gynecol. 146:607-612(1983).
//
RX   PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H;
RA   Rauh-Adelmann, Christine
RA   Lau, Kin-Mang
RA   Sabeti, Nari
RA   Long, John P.
RA   Mok, Samuel C.
RA   Ho, Shuk-Mei
RT   "Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon
RT   12 deletion variant in malignant human ovarian, prostate, and breast
RT   cancer cell lines.";
RL   Mol. Carcinog. 28:236-246(2000).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=22115851; DOI=10.1016/j.ygyno.2011.11.019; PMCID=PMC3468155;
RA   Vishnu, Prakash
RA   Colon-Otero, Gerardo
RA   Kennedy, Gregory T.
RA   Marlow, Laura A.
RA   Kennedy, William P.
RA   Wu, Kevin J.
RA   Santoso, Joseph T.
RA   Copland, John Alton 3rd
RT   "RhoB mediates antitumor synergy of combined ixabepilone and sunitinib
RT   in human ovarian serous cancer.";
RL   Gynecol. Oncol. 124:589-597(2012).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=10318951; DOI=10.1073/pnas.96.10.5722; PMCID=PMC21927;
RA   Lau, Kin-Mang
RA   Mok, Samuel C.
RA   Ho, Shuk-Mei
RT   "Expression of human estrogen receptor-alpha and -beta, progesterone
RT   receptor, and androgen receptor mRNA in normal and malignant ovarian
RT   epithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:5722-5727(1999).
//
RX   PubMed=1536252; DOI=10.1016/0002-9378(92)91697-9;
RA   Berchuck, Andrew
RA   Rodriguez, Gus
RA   Olt, George
RA   Whitaker, Regina
RA   Boente, Matthew P.
RA   Arrick, Bradley A.
RA   Clarke-Pearson, Daniel Lyle
RA   Bast, Robert Clinton Jr.
RT   "Regulation of growth of normal ovarian epithelial cells and ovarian
RT   cancer cell lines by transforming growth factor-beta.";
RL   Am. J. Obstet. Gynecol. 166:676-684(1992).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=7028788; DOI=10.1172/JCI110380; PMCID=PMC370929;
RA   Bast, Robert Clinton Jr.
RA   Feeney, Maryellen
RA   Lazarus, Herbert
RA   Nadler, Lee Marshall
RA   Colvin, Robert B.
RA   Knapp, Robert C.
RT   "Reactivity of a monoclonal antibody with human ovarian carcinoma.";
RL   J. Clin. Invest. 68:1331-1337(1981).
//
RX   PubMed=11793438; DOI=10.1002/gcc.1221;
RA   Rao, Pulivarthi H.
RA   Harris, Charles P.
RA   Lu, Xin-Yan
RA   Li, Xiao-Nan
RA   Mok, Samuel C.
RA   Lau, Ching C.
RT   "Multicolor spectral karyotyping of serous ovarian adenocarcinoma.";
RL   Genes Chromosomes Cancer 33:123-132(2002).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//