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Cellosaurus EA.hy 926 (CVCL_3901)

[Text version]
Cell line name EA.hy 926
Synonyms EA. hy 926; EA hy 926; EA-hy926; EAhy 926; EAHY-926; EA.Hy926; EA.hy926; EAhy926; EaHy926; Eahy926
Accession CVCL_3901
Resource Identification Initiative To cite this cell line use: EA.hy 926 (RRID:CVCL_3901)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Produced by the fusion of A549/8 with human umbilical vein endothelial cells.
Doubling time: 12 hours (PubMed=6407019).
Omics: Transcriptome analysis by microarray.
Anecdotal: Have been flown in space on Shijian-10 and on the ISS in 2016 to study growth and secretion in microgravity (PubMed=28199884; PubMed=30108515; PubMed=30977987).
Misspelling: EA.hy 296; Note=Occasionally.
Misspelling: EA-hy 296; Note=Occasionally.
Misspelling: EA.hy296; Note=Occasionally.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IY87 (A549/8)
Sex of cell Male
Category Hybrid cell line
STR profile Source(s): ATCC


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PubMed=6407019; DOI=10.1073/pnas.80.12.3734
Edgell C.-J.S., McDonald C.C., Graham J.B.
Permanent cell line expressing human factor VIII-related antigen established by hybridization.
Proc. Natl. Acad. Sci. U.S.A. 80:3734-3737(1983)

PubMed=3130908; DOI=10.1182/blood.V71.6.1669.1669
Emeis J.J., Edgell C.-J.S.
Fibrinolytic properties of a human endothelial hybrid cell line (Ea.hy 926).
Blood 71:1669-1675(1988)

PubMed=7791520; DOI=10.1016/0024-3205(95)00227-W
Ahn K., Pan S., Beningo K., Hupe D.
A permanent human cell line (EA.hy926) preserves the characteristics of endothelin converting enzyme from primary human umbilical vein endothelial cells.
Life Sci. 56:2331-2341(1995)

PubMed=12453433; DOI=10.1006/mvre.2002.2434
Unger R.E., Krump-Konvalinkova V., Peters K., Kirkpatrick C.J.
In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R.
Microvasc. Res. 64:384-397(2002)

PubMed=16575254; DOI=10.1097/01.mbc.0000220237.99843.a1
Boerma M., Burton G.R., Wang J.-R., Fink L.M., McGehee R.E. Jr., Hauer-Jensen M.
Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition.
Blood Coagul. Fibrinolysis 17:173-180(2006)

PubMed=26345505; DOI=10.2144/000114326
Lieber D., Hochdorfer D., Stoehr D., Schubert A., Lotfi R., May T., Wirth D., Sinzger C.
A permanently growing human endothelial cell line supports productive infection with human cytomegalovirus under conditional cell growth arrest.
BioTechniques 59:127-136(2015)

PubMed=28199884; DOI=10.1016/j.biomaterials.2017.02.005
Pietsch J., Gass S., Nebuloni S., Echegoyen D., Riwaldt S., Baake C., Bauer J., Corydon T.J., Egli M., Infanger M., Grimm D.
Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission -- the SPHEROIDS project.
Biomaterials 124:126-156(2017)

PubMed=30108515; DOI=10.3389/fphys.2018.01025
Li N., Wang C.-Z., Sun S.-J., Zhang C., Lu D.-Y., Chen Q., Long M.
Microgravity-induced alterations of inflammation-related mechanotransduction in endothelial cells on board SJ-10 satellite.
Front. Physiol. 9:1025.1-1025.15(2018)

PubMed=30977987; DOI=10.33594/000000071
Kruger M., Pietsch J., Bauer J., Kopp S., Carvalho D.T.O., Baatout S., Moreels M., Melnik D., Wehland M., Egli M., Sahana J., Kobbero S.D., Corydon T.J., Nebuloni S., Gass S., Evert M., Infanger M., Grimm D.
Growth of endothelial cells in space and in simulated microgravity -- a comparison on the secretory level.
Cell. Physiol. Biochem. 52:1039-1060(2019)

Cell line collections (Providers) ATCC; CRL-2922
BCRJ; 0345
CLS; 305034
KCB; KCB 2014048YJ
NCBI_Iran; C641
Cell line databases/resources CCRID; 1101HUM-PUMC000475
Cell_Model_Passport; SIDM01986
Lonza; 685
Anatomy/cell type resources BTO; BTO:0000396
Biological sample resources BioSample; SAMN03471700
Chemistry resources ChEMBL-Cells; CHEMBL4295452
ChEMBL-Targets; CHEMBL4296410
PubChem_Cell_line; CVCL_3901
Encyclopedic resources Wikidata; Q54831722
Experimental variables resources EFO; EFO_0003039
Gene expression databases GEO; GSM46371
GEO; GSM46380
GEO; GSM46382
GEO; GSM46383
GEO; GSM46384
GEO; GSM46385
GEO; GSM46392
GEO; GSM46393
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number26