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Cellosaurus Li-7 (CVCL_3840)

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Cell line name Li-7
Synonyms LI7; Li7; C-Li-7
Accession CVCL_3840
Resource Identification Initiative To cite this cell line use: Li-7 (RRID:CVCL_3840)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Part of: Liver Cancer Model Repository (LIMORE).
Population: Japanese.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.93
East Asian, North80.68
East Asian, South17.95
South Asian0
European, North0.44
European, South0
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_XE71 (Li-7-Cas9-751)CVCL_XE72 (Li-7-Cas9-752)CVCL_XE73 (Li-7-Cas9-753)
CVCL_XE74 (Li-7-Cas9-754)CVCL_XE75 (Li-7-Cas9-755)CVCL_XE76 (Li-7-Cas9-756)
CVCL_XE77 (Li-7-Cas9-757)CVCL_XE78 (Li-7-Cas9-758)CVCL_XE79 (Li-7-Cas9-759)
CVCL_XE80 (Li-7-Cas9-760)CVCL_XE70 (Li-7-Luc2-tdT)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=25877200; PubMed=31378681; RCB=RCB1941; TKG=TKG 0368

Markers:
AmelogeninX
CSF1PO12
D2S133817,19
D3S135815,16
D5S8189,11
D7S82010,11
D8S117913,14
D13S31711
D16S5399
D18S5116
D19S43312,14
D21S1130
FGA20
Penta D10
Penta E5
TH017
TPOX8 (TKG=TKG 0368)
8,11 (CCRID; PubMed=25877200; PubMed=31378681; RCB=RCB1941)
vWA16,19

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/Li7
Provider; BRICS; BRICS0080; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3894
Publications

PubMed=85491
Setsuo Hirohashi, Yukio Shimosato, Toru Kameya, Tsutomu Koide, Tatsu Mukojima, Yumiko Taguchi, Keizo Kageyama;
Production of alpha-fetoprotein and normal serum proteins by xenotransplanted human hepatomas in relation to their growth and morphology.
Cancer Res. 39:1819-1828(1979)

PubMed=2542205; DOI=10.1111/j.1349-7006.1989.tb02290.x; PMCID=PMC5917712
Hitoshi Tsuda, Setsuo Hirohashi, Yukio Shimosato, Yoshinori Ino, Teruhiko Yoshida, Masaaki Terada;
Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.
Jpn. J. Cancer Res. 80:196-199(1989)

PubMed=12029633; DOI=10.1053/jhep.2002.33683
Kohichiroh Yasui, Shigeki Arii, Chen Zhao, Issei Imoto, Masakazu Ueda, Hisaki Nagai, Mitsuru Emi, Johji Inazawa;
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Hepatology 35:1476-1484(2002)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Noriyuki Nakatsu, Yoko Yoshida, Kanami Yamazaki, Tomoki Nakamura, Shingo Dan, Yasuhisa Fukui, Takao Yamori;
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Jean-Charles Nault, Maxime Mallet, Camilla Pilati, Julien Calderaro, Paulette Bioulac-Sage, Christophe Laurent, Alexis Laurent, Daniel Cherqui, Charles Balabaud, Jessica Zucman-Rossi;
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30784169; DOI=10.1111/cas.13978; PMCID=PMC6500967
Yukako Sato, Takeshi Yamada, Takashi Hiroyama, Kazuhiro Sudo, Naoyuki Hasegawa, Ichinosuke Hyodo, Yukio Nakamura;
A robust culture method for maintaining tumorigenic cancer stem cells in the hepatocellular carcinoma cell line Li-7.
Cancer Sci. 110:1644-1652(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Stefano Caruso, Anna-Line Calatayud, Jill Pilet, Tiziana La Bella, Samia Rekik, Sandrine Imbeaud, Eric Letouze, Lea Meunier, Quentin Bayard, Nataliya Rohr-Udilova, Camille Peneau ...Show all 20 authors... , Bettina Grasl-Kraupp, Leanne de Koning, Berengere Ouine, Paulette Bioulac-Sage, Gabrielle Couchy, Julien Calderaro, Jean-Charles Nault, Jessica Zucman-Rossi, Sandra Rebouissou; Show fewer authors
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

PubMed=37610679; DOI=10.1007/s13577-023-00967-7; PMCID=PMC10587214
Yusuke Seyama, Kazuhiro Sudo, Suguru Hirose, Yukako Hamano, Takeshi Yamada, Takashi Hiroyama, Ryosuke Sasaki, Masami Yokota Hirai, Ichinosuke Hyodo, Kiichiro Tsuchiya, Yukio Nakamura;
Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7.
Hum. Cell 36:2074-2086(2023)

Cross-references
Cell line collections (Providers) CLS; 305102
RCB; RCB1941
TKG; TKG 0368
Cell line databases/resources CLO; CLO_0050854
cancercelllines; CVCL_3840
CCRID; 1101HUM-PUMC000678
CCRID; 3101HUMSCSP5062
CCRID; 3101HUMTCHu183
Cell_Model_Passport; SIDM01472
CGH-DB; 9074-4
DepMap; ACH-000471
LIMORE; Li7
Biological sample resources BioSample; SAMN03470992
BioSample; SAMN10987749
CRISP screens repositories BioGRID_ORCS_Cell_line; 571
Chemistry resources PharmacoDB; Li7_835_2019
Encyclopedic resources Wikidata; Q54902491
Gene expression databases ArrayExpress; E-MTAB-2770
FANTOM5_SSTAR; 10484-107A7
GEO; GSM565882
GEO; GSM887266
GEO; GSM888341
GEO; GSM2551577
Polymorphism and mutation databases Cosmic; 721062
Cosmic; 2023862
Cosmic; 2162529
Cosmic; 2771607
IARC_TP53; 30113
LiGeA; CCLE_219
Progenetix; CVCL_3840
Proteomic databases PRIDE; PXD002486
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37