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Cellosaurus Li-7 (CVCL_3840)

[Text version]
Cell line name Li-7
Synonyms LI7; Li7; C-Li-7
Accession CVCL_3840
Resource Identification Initiative To cite this cell line use: Li-7 (RRID:CVCL_3840)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Part of: Liver Cancer Model Repository (LIMORE).
Population: Japanese.
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.93
East Asian, North80.68
East Asian, South17.95
South Asian0
European, North0.44
European, South0
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_XE71 (Li-7-Cas9-751)CVCL_XE72 (Li-7-Cas9-752)CVCL_XE73 (Li-7-Cas9-753)
CVCL_XE74 (Li-7-Cas9-754)CVCL_XE75 (Li-7-Cas9-755)CVCL_XE76 (Li-7-Cas9-756)
CVCL_XE77 (Li-7-Cas9-757)CVCL_XE78 (Li-7-Cas9-758)CVCL_XE79 (Li-7-Cas9-759)
CVCL_XE80 (Li-7-Cas9-760)CVCL_XE70 (Li-7-Luc2-tdT)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=25877200; PubMed=31378681; RCB; TKG

Penta D10
Penta E5
8,11 (CCRID; PubMed=25877200; PubMed=31378681; RCB)

Run an STR similarity search on this cell line
Web pages https://lccl.zucmanlab.com/hcc/cellLines/Li7

Hirohashi S., Shimosato Y., Kameya T., Koide T., Mukojima T., Taguchi Y., Kageyama K.
Production of alpha-fetoprotein and normal serum proteins by xenotransplanted human hepatomas in relation to their growth and morphology.
Cancer Res. 39:1819-1828(1979)

PubMed=2542205; DOI=10.1111/j.1349-7006.1989.tb02290.x
Tsuda H., Hirohashi S., Shimosato Y., Ino Y., Yoshida T., Terada M.
Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.
Jpn. J. Cancer Res. 80:196-199(1989)

PubMed=12029633; DOI=10.1053/jhep.2002.33683
Yasui K., Arii S., Zhao C., Imoto I., Ueda M., Nagai H., Emi M., Inazawa J.
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Hepatology 35:1476-1484(2002)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23887712; DOI=10.1038/ncomms3218
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30784169; DOI=10.1111/cas.13978
Sato Y., Yamada T., Hiroyama T., Sudo K., Hasegawa N., Hyodo I., Nakamura Y.
A robust culture method for maintaining tumorigenic cancer stem cells in the hepatocellular carcinoma cell line Li-7.
Cancer Sci. 110:1644-1652(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

PubMed=37610679; DOI=10.1007/s13577-023-00967-7
Seyama Y., Sudo K., Hirose S., Hamano Y., Yamada T., Hiroyama T., Sasaki R., Hirai M.Y., Hyodo I., Tsuchiya K., Nakamura Y.
Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7.
Hum. Cell 36:2074-2086(2023)

Cell line collections (Providers) CLS; 305102
RCB; RCB1941
TKG; TKG 0368
Cell line databases/resources CLO; CLO_0050854
cancercelllines; CVCL_3840
CCRID; 1101HUM-PUMC000678
Cell_Model_Passport; SIDM01472
CGH-DB; 9074-4
DepMap; ACH-000471
Biological sample resources BioSample; SAMN03470992
BioSample; SAMN10987749
CRISP screens repositories BioGRID_ORCS_Cell_line; 571
Chemistry resources PharmacoDB; Li7_835_2019
Encyclopedic resources Wikidata; Q54902491
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM565882
GEO; GSM887266
GEO; GSM888341
GEO; GSM2551577
Polymorphism and mutation databases Cosmic; 721062
Cosmic; 2023862
Cosmic; 2162529
Cosmic; 2771607
IARC_TP53; 30113
LiGeA; CCLE_219
Progenetix; CVCL_3840
Proteomic databases PRIDE; PXD002486
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number34