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Cellosaurus THLE-3 (CVCL_3804)

[Text version]
Cell line name THLE-3
Synonyms THLE3; Transformed Human Liver Epithelial-3
Accession CVCL_3804
Resource Identification Initiative To cite this cell line use: THLE-3 (RRID:CVCL_3804)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11233.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
STR profile Source(s): AddexBio; ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81813
D7S8208,10
D13S31713
D16S53911,12
TH018,9.3
TPOX6,9
vWA17,18

Run an STR similarity search on this cell line
Publications

DOI=10.1007/978-1-4612-0411-4_31
Lechner J.F., Smoot D.T., Pfeifer A.M.A., Cole K.H., Weston A., Groopman J.D., Shields P.G., Tokiwa T., Harris C.C.
A non-tumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.307-321; Humana Press; New York (1990)

PubMed=7685115; DOI=10.1073/pnas.90.11.5123
Pfeifer A.M.A., Cole K.E., Smoot D.T., Weston A., Groopman J.D., Shields P.G., Vignaud J.-M., Juillerat M., Lipsky M.M., Trump B.F., Lechner J.F., Harris C.C.
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.
Proc. Natl. Acad. Sci. U.S.A. 90:5123-5127(1993)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

Patent=US5759765
Harris C.C., Cole K.H., Lechner J.F., Reddel R.R.
Human liver epithelial cell lines.
Patent number US5759765, 02-Jun-1998

PubMed=23887712; DOI=10.1038/ncomms3218
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

Cross-references
Cell line collections (Providers) AddexBio; T0015002/4913
ATCC; CRL-11233
KCB; KCB 2019018YJ
Cell line databases/resources CLO; CLO_0009347
CCRID; 3101HUMGNHu40
CCRID; 5301HUM-KCB19018YJ
Biological sample resources BioSample; SAMN03471331
Encyclopedic resources Wikidata; Q54972311
Polymorphism and mutation databases Cosmic; 2162543
IARC_TP53; 23554
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number22