ID   THLE-3
AC   CVCL_3804
SY   THLE3; Transformed Human Liver Epithelial-3
DR   CLO; CLO_0009347
DR   AddexBio; T0015002/4913
DR   ATCC; CRL-11233
DR   BioSample; SAMN03471331
DR   CCRID; 3101HUMGNHu40
DR   CCRID; 5301HUM-KCB19018YJ
DR   Cosmic; 2162543
DR   IARC_TP53; 23554
DR   KCB; KCB 2019018YJ
DR   Wikidata; Q54972311
RX   DOI=10.1007/978-1-4612-0411-4_31;
RX   Patent=US5759765;
RX   PubMed=7685115;
RX   PubMed=8504475;
RX   PubMed=23887712;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11233.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): AddexBio; ATCC
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 13
ST   D16S539: 11,12
ST   D5S818: 13
ST   D7S820: 8,10
ST   TH01: 8,9.3
ST   TPOX: 6,9
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 22
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RX   DOI=10.1007/978-1-4612-0411-4_31;
RA   Lechner J.F., Smoot D.T., Pfeifer A.M.A., Cole K.H., Weston A.,
RA   Groopman J.D., Shields P.G., Tokiwa T., Harris C.C.;
RT   "A non-tumorigenic human liver epithelial cell culture model for
RT   chemical and biological carcinogenesis investigations.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.307-321; Humana Press; New York (1990).
//
RX   Patent=US5759765;
RA   Harris C.C., Cole K.H., Lechner J.F., Reddel R.R.;
RT   "Human liver epithelial cell lines.";
RL   Patent number US5759765, 02-Jun-1998.
//
RX   PubMed=7685115; DOI=10.1073/pnas.90.11.5123;
RA   Pfeifer A.M.A., Cole K.E., Smoot D.T., Weston A., Groopman J.D.,
RA   Shields P.G., Vignaud J.-M., Juillerat M., Lipsky M.M., Trump B.F.,
RA   Lechner J.F., Harris C.C.;
RT   "Simian virus 40 large tumor antigen-immortalized normal human liver
RT   epithelial cells express hepatocyte characteristics and metabolize
RT   chemical carcinogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:5123-5127(1993).
//
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P.,
RA   Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M.,
RA   Harris C.C.;
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
//
RX   PubMed=23887712; DOI=10.1038/ncomms3218;
RA   Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P.,
RA   Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.;
RT   "High frequency of telomerase reverse-transcriptase promoter somatic
RT   mutations in hepatocellular carcinoma and preneoplastic lesions.";
RL   Nat. Commun. 4:2218.1-2218.7(2013).
//