ID   THLE-3
AC   CVCL_3804
SY   THLE3; Transformed Human Liver Epithelial-3
DR   CLO; CLO_0009347
DR   AddexBio; T0015002/4913
DR   ATCC; CRL-3583
DR   ATCC; CRL-11233
DR   BioSample; SAMN03471331
DR   CCRID; 3101HUMGNHu40
DR   CCRID; 5301HUM-KCB19018YJ
DR   Cosmic; 2162543
DR   IARC_TP53; 23554
DR   KCB; KCB 2019018YJ
DR   Wikidata; Q54972311
RX   DOI=10.1007/978-1-4612-0411-4_31;
RX   Patent=US5759765;
RX   PubMed=7685115;
RX   PubMed=8504475;
RX   PubMed=23887712;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11233.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Discontinued: ATCC; CRL-11233; true.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): AddexBio=T0015002/4913; ATCC=CRL-3583
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 13
ST   D16S539: 11,12
ST   D5S818: 13
ST   D7S820: 8,10
ST   TH01: 8,9.3
ST   TPOX: 6,9
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
//
RX   DOI=10.1007/978-1-4612-0411-4_31;
RA   Lechner, John F.
RA   Smoot, Duane T.
RA   Pfeifer, Andrea M.A.
RA   Cole, Katharine H.
RA   Weston, Ainsley
RA   Groopman, John Davis
RA   Shields, Peter G.
RA   Tokiwa, Takayoshi
RA   Harris, Curtis Craig
RT   "A non-tumorigenic human liver epithelial cell culture model for
RT   chemical and biological carcinogenesis investigations.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.307-321; Humana Press; New York; USA (1990).
//
RX   PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665;
RA   Nault, Jean-Charles
RA   Mallet, Maxime
RA   Pilati, Camilla
RA   Calderaro, Julien
RA   Bioulac-Sage, Paulette
RA   Laurent, Christophe
RA   Laurent, Alexis
RA   Cherqui, Daniel
RA   Balabaud, Charles
RA   Zucman-Rossi, Jessica
RT   "High frequency of telomerase reverse-transcriptase promoter somatic
RT   mutations in hepatocellular carcinoma and preneoplastic lesions.";
RL   Nat. Commun. 4:2218.1-2218.7(2013).
//
RX   PubMed=7685115; DOI=10.1073/pnas.90.11.5123; PMCID=PMC46667;
RA   Pfeifer, Andrea M.A.
RA   Cole, Katherine E.
RA   Smoot, Duane T.
RA   Weston, Ainsley
RA   Groopman, John Davis
RA   Shields, Peter G.
RA   Vignaud, Jean-Michel
RA   Juillerat, Michel
RA   Lipsky, Michael M.
RA   Trump, Benjamin Franklin
RA   Lechner, John F.
RA   Harris, Curtis Craig
RT   "Simian virus 40 large tumor antigen-immortalized normal human liver
RT   epithelial cells express hepatocyte characteristics and metabolize
RT   chemical carcinogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:5123-5127(1993).
//
RX   Patent=US5759765;
RA   Harris, Curtis Craig
RA   Cole, Katharine H.
RA   Lechner, John F.
RA   Reddel, Roger Robert
RT   "Human liver epithelial cell lines.";
RL   Patent number US5759765, 02-Jun-1998.
//
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman, Teresa A.
RA   Modali, Ramakrishna V.
RA   Boukamp, Petra
RA   Stanek, Julie
RA   Bennett, William P.
RA   Welsh, Judith A.
RA   Metcalf, Robert A.
RA   Stampfer, Martha Ruskin
RA   Fusenig, Norbert E.
RA   Rogan, Eileen M.
RA   Harris, Curtis Craig
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
//