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Cellosaurus RWPE-1 (CVCL_3791)

[Text version]
Cell line name RWPE-1
Synonyms RWPE1
Accession CVCL_3791
Resource Identification Initiative To cite this cell line use: RWPE-1 (RRID:CVCL_3791)
Comments Group: Patented cell line.
Part of: ENCODE project common cell types; tier 3.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11609.
Population: Caucasian.
Doubling time: ~22 hours (PBCF).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Genomics; DNA methylation analysis.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Prostate, epithelium; UBERON=UBERON_0000428.
Cell type: Epithelial cell of prostate; CL=CL_0002231.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4794 (CTPE)CVCL_3792 (RWPE-2)CVCL_K282 (WPE-int)
CVCL_K283 (WPE-stem)CVCL_3810 (WPE1-NA22)CVCL_3811 (WPE1-NB11)
CVCL_3812 (WPE1-NB14)CVCL_3813 (WPE1-NB26)
Originate from same individual CVCL_3814 ! WPMY-1
Sex of cell Male
Age at sampling 54Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-3607; CLS=305217; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO13
D3S135815,16
D5S81812,15
D7S82010,11
D8S117910,14
D13S3178,14
D16S5399,11
D18S5114,16
D21S1129,31
FGA24,25
Penta D10,13
Penta E5,12
TH018,9.3
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/RWPE_Crawford_protocol.pdf
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544576
Publications

PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6
Mukta M. Webber, Diana Bello, Salmaan T.A. Quader;
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines.
Prostate 29:386-394(1996)

PubMed=9214605; DOI=10.1093/carcin/18.6.1215
Diana Bello, Mukta M. Webber, Hynda Karen Kleinman, David Don Wartinger, Johng Sik Rhim;
Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18.
Carcinogenesis 18:1215-1223(1997)

PubMed=9214606; DOI=10.1093/carcin/18.6.1225
Mukta M. Webber, Diana Bello, Hynda Karen Kleinman, Matthew P. Hoffman;
Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.
Carcinogenesis 18:1225-1231(1997)

Patent=US6255058
Mukta M. Webber, Johng Sik Rhim;
Immortalized and malignant human prostatic cell lines.
Patent number US6255058, 03-Jul-2001

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22275356; DOI=10.1074/jbc.M111.302547; PMCID=PMC3322861
Thomas P. Lynch, Christina M. Ferrer, S. RaElle Jackson, Kristina S. Shahriari, Keith Vosseller, Mauricio J. Reginato;
Critical role of O-linked beta-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.
J. Biol. Chem. 287:11070-11081(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30305041; DOI=10.1186/s12885-018-4848-x; PMCID=PMC6180441
Kasey Jividen, Katarzyna Z. Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan, Bryce M. Paschal;
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
BMC Cancer 18:960.1-960.20(2018)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132; PMCID=PMC6548687
Stanley Eugene Hooker Jr., Leanne Woods-Burnham, Madhavi Bathina, Stacy Lloyd, Priyatham Gorjala, Ranjana Mitra, Larisa Nonn, K. Sean Kimbro, Rick Antonius Kittles;
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-3607
ATCC; CRL-11609 - Discontinued
BCRJ; 0389
CCTCC; GDC0178
CLS; 305217
Cell line databases/resources CLO; CLO_0008905
cancercelllines; CVCL_3791
CCRID; 3101HUMGNHu37
CCRID; 3101HUMSCSP5025
CCRID; 4201HUM-CCTCC00178
Cell_Model_Passport; SIDM00020
IGRhCellID; RWPE1
Lonza; 870
Anatomy/cell type resources BTO; BTO_0003709
Biological sample resources BioSample; SAMN03470832
BioSample; SAMN05292437
BioSample; SAMN07709991
BioSample; SAMN07709992
BioSample; SAMN07709993
BioSample; SAMN07709994
BioSample; SAMN07709995
BioSample; SAMN07709996
BioSample; SAMN07709997
ENCODE; ENCBS124FCL
ENCODE; ENCBS192LWI
ENCODE; ENCBS263AAA
ENCODE; ENCBS875FPF
Chemistry resources ChEMBL-Cells; CHEMBL4295468
ChEMBL-Targets; CHEMBL4296492
PharmacoDB; RWPE1_1336_2019
PubChem_Cell_line; CVCL_3791
Encyclopedic resources Wikidata; Q54951497
Experimental variables resources EFO; EFO_0002323
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-3610
GEO; GSM827387
GEO; GSM1008595
GEO; GSM1374860
GEO; GSM1670396
Polymorphism and mutation databases Progenetix; CVCL_3791
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39